Essential role for Vav1 in activation, but not development, of γδ T cells

Wojciech Swat, Ramnik Xavier, Atsushi Mizoguchi, Emiko Mizoguchi, Jessica Fredericks, Keiko Fujikawa, Atul K. Bhan, Frederick W. Alt

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Vav1 is a guanine nucleotide exchange factor essential in the development and function of αβ lineage T cells. Here we report that in contrast to profound effects on pre-TCR- or αβ TCR-dependent events in thymocyte development, Vav1 deficiency has no detectable effect on the development of γδ T cells. Strikingly, however, these γδ T cells are markedly deficient in signaling through the γδ TCR, as evidenced by a lack of proliferation and cytokine production in response to stimulation with anti-γδ TCR antibodies. We propose that Vav1 has a unique and non-redundant role in the initiation of signaling downstream of the γδ TCR in lymphocytes.

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalInternational Immunology
Volume15
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Antigen receptor
  • Intestinal epithelial
  • Lymphocyte
  • Lymphocyte activation
  • Lymphocyte development
  • Vav1

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