Essential flexibility in the T-cell recognition of antigen

Gilbert J. Kersh; Paul M. Allen

doi:10.1038/380495a0

Essential flexibility in the T-cell recognition of antigen

Gilbert J. Kersh, Paul M. Allen

Research output: Contribution to journal › Short survey › peer-review

295 Scopus citations

Abstract

αβ T cells specifically recognize a ligand composed of a peptide bound to a self-major-histocompatibility-complex molecule, but the recognition of slightly altered ligands by T cells can lead to a partial activation. This flexibility is crucial for T-cell development and can have both beneficial and harmful effects on peripheral T cells.

Original language	English
Pages (from-to)	495-498
Number of pages	4
Journal	Nature
Volume	380
Issue number	6574
DOIs	https://doi.org/10.1038/380495a0
State	Published - Apr 11 1996

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title = "Essential flexibility in the T-cell recognition of antigen",

abstract = "αβ T cells specifically recognize a ligand composed of a peptide bound to a self-major-histocompatibility-complex molecule, but the recognition of slightly altered ligands by T cells can lead to a partial activation. This flexibility is crucial for T-cell development and can have both beneficial and harmful effects on peripheral T cells.",

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AU - Allen, Paul M.

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AB - αβ T cells specifically recognize a ligand composed of a peptide bound to a self-major-histocompatibility-complex molecule, but the recognition of slightly altered ligands by T cells can lead to a partial activation. This flexibility is crucial for T-cell development and can have both beneficial and harmful effects on peripheral T cells.

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JO - Nature

JF - Nature

IS - 6574

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Essential flexibility in the T-cell recognition of antigen

Abstract

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