Essential flexibility in the T-cell recognition of antigen

Gilbert J. Kersh, Paul M. Allen

Research output: Contribution to journalShort survey

286 Scopus citations

Abstract

αβ T cells specifically recognize a ligand composed of a peptide bound to a self-major-histocompatibility-complex molecule, but the recognition of slightly altered ligands by T cells can lead to a partial activation. This flexibility is crucial for T-cell development and can have both beneficial and harmful effects on peripheral T cells.

Original languageEnglish
Pages (from-to)495-498
Number of pages4
JournalNature
Volume380
Issue number6574
DOIs
StatePublished - Apr 11 1996

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