Escitalopram reduces attentional performance in anxious older adults with high-expression genetic variants at serotonin 2A and 1B receptors

Eric J. Lenze, David Dixon, Petra Nowotny, Francis E. Lotrich, Peter M. Doré, Bruce G. Pollock, Anthony L. Hinrichs, Meryl A. Butters

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Older adults are among the most vulnerable to adverse cognitive effects of psychotropic medications and, therefore, the personalization of psychotropic treatment based on adverse drug reactions in this demographic is of great importance. We examined changes on neuropsychological tests of attention attributable to selective serotonin reuptake inhibitor (SSRI) treatment in anxious older adults. We also examined whether variation in serotonin receptor genes was associated with reduced attentional performance with SSRIs. We examined change from pre- to post-treatment in two attention measures - digit span and coding - in 133 adults aged â

Original languageEnglish
Pages (from-to)279-288
Number of pages10
JournalInternational Journal of Neuropsychopharmacology
Volume16
Issue number2
DOIs
StatePublished - Mar 2013

Keywords

  • Anxiety
  • antidepressant
  • elderly
  • neuropsychological functioning
  • pharmacogenomics

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