TY - JOUR
T1 - Escape of mutant double-stranded DNA virus from innate immune control
AU - French, Anthony R.
AU - Pingel, Jeanette T.
AU - Wagner, Markus
AU - Bubic, Ivan
AU - Yang, Liping
AU - Kim, Sungjin
AU - Koszinowski, Ulrich
AU - Jonjic, Stipan
AU - Yokoyama, Wayne M.
N1 - Funding Information:
This work was supported by an HHMI Faculty Development Award to A.R.F. and by the Barnes-Jewish Hospital Research Foundation and NIH grants to W.M.Y., who is a HHMI investigator. U.H.K. and M.W. were supported by the Deutsche Forschungsgemeinschaft. We thank Anthony Scalzo for helpful discussions and Stephanie Wooten for technical assistance, as well as Leon Carayannopoulos, Skip Virgin, and Marco Colonna for critical reading of this manuscript. This paper is dedicated to the memory of Charlie Janeway, who encouraged us to do experiments on NK cell memory that led to the initial observation shown in Figure 1 .
PY - 2004/6
Y1 - 2004/6
N2 - As innate immune system components, natural killer (NK) cells respond rapidly to infections and effectively control replication of pathogens, including murine cytomegalovirus (MCMV), a double-stranded DNA β-herpesvirus. In the absence of NK cell control, MCMV infection results in early mortality due to uncontrolled viral replication. However, here we show that even in the face of initial NK cell control, there is late recrudescence of disease and mortality in immunodeficient mice due to the outgrowth of MCMV mutants that escape recognition by innate NK cells. These data suggest that viral infections in certain clinical settings also may be due to viral escape from innate immunity.
AB - As innate immune system components, natural killer (NK) cells respond rapidly to infections and effectively control replication of pathogens, including murine cytomegalovirus (MCMV), a double-stranded DNA β-herpesvirus. In the absence of NK cell control, MCMV infection results in early mortality due to uncontrolled viral replication. However, here we show that even in the face of initial NK cell control, there is late recrudescence of disease and mortality in immunodeficient mice due to the outgrowth of MCMV mutants that escape recognition by innate NK cells. These data suggest that viral infections in certain clinical settings also may be due to viral escape from innate immunity.
UR - http://www.scopus.com/inward/record.url?scp=2942579946&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2004.05.006
DO - 10.1016/j.immuni.2004.05.006
M3 - Article
C2 - 15189739
AN - SCOPUS:2942579946
SN - 1074-7613
VL - 20
SP - 747
EP - 756
JO - Immunity
JF - Immunity
IS - 6
ER -