Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

Sarah B. Mulkey; Raghu H. Ramakrishnaiah; Robert C. McKinstry; Taeun Chang; Amit M. Mathur; Dennis E. Mayock; Krisa P. Van Meurs; G. Bradley Schaefer; Chunqiao Luo; Shasha Bai; Sandra E. Juul; Yvonne W. Wu

doi:10.1016/j.jpeds.2017.03.053

Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

Sarah B. Mulkey
, Raghu H. Ramakrishnaiah
, Robert C. McKinstry
, Taeun Chang
, Amit M. Mathur
, Dennis E. Mayock
, Krisa P. Van Meurs
, G. Bradley Schaefer
, Chunqiao Luo
, Shasha Bai
, Sandra E. Juul
, Yvonne W. Wu

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P =.004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. Trial registration ClinicalTrials.gov: NCT01913340.

Original language	English
Pages (from-to)	196-199
Number of pages	4
Journal	Journal of Pediatrics
Volume	186
DOIs	https://doi.org/10.1016/j.jpeds.2017.03.053
State	Published - Jul 2017

Keywords

brain volumetrics
diffusion weighted imaging
neuroprotection
newborn

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10.1016/j.jpeds.2017.03.053

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Mulkey, S. B., Ramakrishnaiah, R. H., McKinstry, R. C., Chang, T., Mathur, A. M., Mayock, D. E., Van Meurs, K. P., Schaefer, G. B., Luo, C., Bai, S., Juul, S. E., & Wu, Y. W. (2017). Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome. Journal of Pediatrics, 186, 196-199. https://doi.org/10.1016/j.jpeds.2017.03.053

@article{57c6c4ff39bf49a980d5d88488a1b50b,

title = "Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome",

abstract = "In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P =.004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. Trial registration ClinicalTrials.gov: NCT01913340.",

keywords = "brain volumetrics, diffusion weighted imaging, neuroprotection, newborn",

author = "Mulkey, \{Sarah B.\} and Ramakrishnaiah, \{Raghu H.\} and McKinstry, \{Robert C.\} and Taeun Chang and Mathur, \{Amit M.\} and Mayock, \{Dennis E.\} and \{Van Meurs\}, \{Krisa P.\} and Schaefer, \{G. Bradley\} and Chunqiao Luo and Shasha Bai and Juul, \{Sandra E.\} and Wu, \{Yvonne W.\}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = jul,

doi = "10.1016/j.jpeds.2017.03.053",

language = "English",

volume = "186",

pages = "196--199",

journal = "Journal of Pediatrics",

issn = "0022-3476",

}

Mulkey, SB, Ramakrishnaiah, RH, McKinstry, RC, Chang, T, Mathur, AM, Mayock, DE, Van Meurs, KP, Schaefer, GB, Luo, C, Bai, S, Juul, SE & Wu, YW 2017, 'Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome', Journal of Pediatrics, vol. 186, pp. 196-199. https://doi.org/10.1016/j.jpeds.2017.03.053

TY - JOUR

T1 - Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy

T2 - Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

AU - Mulkey, Sarah B.

AU - Ramakrishnaiah, Raghu H.

AU - McKinstry, Robert C.

AU - Chang, Taeun

AU - Mathur, Amit M.

AU - Mayock, Dennis E.

AU - Van Meurs, Krisa P.

AU - Schaefer, G. Bradley

AU - Luo, Chunqiao

AU - Bai, Shasha

AU - Juul, Sandra E.

AU - Wu, Yvonne W.

PY - 2017/7

Y1 - 2017/7

N2 - In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P =.004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. Trial registration ClinicalTrials.gov: NCT01913340.

AB - In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P =.004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. Trial registration ClinicalTrials.gov: NCT01913340.

KW - brain volumetrics

KW - diffusion weighted imaging

KW - neuroprotection

KW - newborn

UR - https://www.scopus.com/pages/publications/85018704348

U2 - 10.1016/j.jpeds.2017.03.053

DO - 10.1016/j.jpeds.2017.03.053

M3 - Article

C2 - 28456387

AN - SCOPUS:85018704348

SN - 0022-3476

VL - 186

SP - 196

EP - 199

JO - Journal of Pediatrics

JF - Journal of Pediatrics

ER -

Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

Abstract

Keywords

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