Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

Sarah B. Mulkey, Raghu H. Ramakrishnaiah, Robert C. McKinstry, Taeun Chang, Amit M. Mathur, Dennis E. Mayock, Krisa P. Van Meurs, G. Bradley Schaefer, Chunqiao Luo, Shasha Bai, Sandra E. Juul, Yvonne W. Wu

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P =.004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. Trial registration ClinicalTrials.gov: NCT01913340.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalJournal of Pediatrics
Volume186
DOIs
StatePublished - Jul 2017

Keywords

  • brain volumetrics
  • diffusion weighted imaging
  • neuroprotection
  • newborn

Fingerprint Dive into the research topics of 'Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome'. Together they form a unique fingerprint.

  • Cite this

    Mulkey, S. B., Ramakrishnaiah, R. H., McKinstry, R. C., Chang, T., Mathur, A. M., Mayock, D. E., Van Meurs, K. P., Schaefer, G. B., Luo, C., Bai, S., Juul, S. E., & Wu, Y. W. (2017). Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome. Journal of Pediatrics, 186, 196-199. https://doi.org/10.1016/j.jpeds.2017.03.053