Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

Sarah B. Mulkey; Raghu H. Ramakrishnaiah; Robert C. McKinstry; Taeun Chang; Amit M. Mathur; Dennis E. Mayock; Krisa P. Van Meurs; G. Bradley Schaefer; Chunqiao Luo; Shasha Bai; Sandra E. Juul; Yvonne W. Wu

doi:10.1016/j.jpeds.2017.03.053

Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

Sarah B. Mulkey, Raghu H. Ramakrishnaiah, Robert C. McKinstry, Taeun Chang, Amit M. Mathur, Dennis E. Mayock, Krisa P. Van Meurs, G. Bradley Schaefer, Chunqiao Luo, Shasha Bai, Sandra E. Juul, Yvonne W. Wu

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P =.004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. Trial registration ClinicalTrials.gov: NCT01913340.

Original language	English
Pages (from-to)	196-199
Number of pages	4
Journal	Journal of Pediatrics
Volume	186
DOIs	https://doi.org/10.1016/j.jpeds.2017.03.053
State	Published - Jul 2017

Keywords

brain volumetrics
diffusion weighted imaging
neuroprotection
newborn

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Mulkey, S. B., Ramakrishnaiah, R. H., McKinstry, R. C., Chang, T., Mathur, A. M., Mayock, D. E., Van Meurs, K. P., Schaefer, G. B., Luo, C., Bai, S., Juul, S. E., & Wu, Y. W. (2017). Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome. Journal of Pediatrics, 186, 196-199. https://doi.org/10.1016/j.jpeds.2017.03.053

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title = "Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome",

abstract = "In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P =.004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. Trial registration ClinicalTrials.gov: NCT01913340.",

keywords = "brain volumetrics, diffusion weighted imaging, neuroprotection, newborn",

author = "Mulkey, {Sarah B.} and Ramakrishnaiah, {Raghu H.} and McKinstry, {Robert C.} and Taeun Chang and Mathur, {Amit M.} and Mayock, {Dennis E.} and {Van Meurs}, {Krisa P.} and Schaefer, {G. Bradley} and Chunqiao Luo and Shasha Bai and Juul, {Sandra E.} and Wu, {Yvonne W.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = jul,

doi = "10.1016/j.jpeds.2017.03.053",

language = "English",

volume = "186",

pages = "196--199",

journal = "Journal of Pediatrics",

issn = "0022-3476",

}

Mulkey, SB, Ramakrishnaiah, RH, McKinstry, RC, Chang, T, Mathur, AM, Mayock, DE, Van Meurs, KP, Schaefer, GB, Luo, C, Bai, S, Juul, SE & Wu, YW 2017, 'Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome', Journal of Pediatrics, vol. 186, pp. 196-199. https://doi.org/10.1016/j.jpeds.2017.03.053

TY - JOUR

T1 - Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy

T2 - Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

AU - Mulkey, Sarah B.

AU - Ramakrishnaiah, Raghu H.

AU - McKinstry, Robert C.

AU - Chang, Taeun

AU - Mathur, Amit M.

AU - Mayock, Dennis E.

AU - Van Meurs, Krisa P.

AU - Schaefer, G. Bradley

AU - Luo, Chunqiao

AU - Bai, Shasha

AU - Juul, Sandra E.

AU - Wu, Yvonne W.

PY - 2017/7

Y1 - 2017/7

N2 - In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P =.004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. Trial registration ClinicalTrials.gov: NCT01913340.

AB - In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P =.004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. Trial registration ClinicalTrials.gov: NCT01913340.

KW - brain volumetrics

KW - diffusion weighted imaging

KW - neuroprotection

KW - newborn

UR - http://www.scopus.com/inward/record.url?scp=85018704348&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2017.03.053

DO - 10.1016/j.jpeds.2017.03.053

M3 - Article

C2 - 28456387

AN - SCOPUS:85018704348

SN - 0022-3476

VL - 186

SP - 196

EP - 199

JO - Journal of Pediatrics

JF - Journal of Pediatrics

ER -

Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

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Keywords

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