Erratum: Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells (Cell Metabolism (2016) 23(5) (852–866) (S1550413116301619) (10.1016/j.cmet.2016.04.010))

Tae Jin Yun, Jun Seong Lee, Kawthar Machmach, Dahee Shim, Junhee Choi, Young Jin Wi, Hyung Seok Jang, In Hyuk Jung, Kyeongdae Kim, Won Kee Yoon, Mohammad Alam Miah, Bin Li, Jinsam Chang, Mariana G. Bego, Tram N.Q. Pham, Jakob Loschko, Jörg Hermann Fritz, Anne B. Krug, Seung Pyo Lee, Tibor KelerJean V. Guimond, Elie Haddad, Eric A. Cohen, Martin G. Sirois, Ismail El-Hamamsy, Marco Colonna, Goo Taeg Oh, Jae Hoon Choi, Cheolho Cheong

Research output: Contribution to journalComment/debate

6 Scopus citations

Abstract

(Cell Metabolism 23, 852–866; May 10, 2016) In the preparation and publication of this article, one figure showing the efficacy of prolonged plasmacytoid dendritic cell (pDC) depletion in BDCA2-DTR bone marrow (BM) reconstituted mice was omitted from the manuscript due to author oversight. To selectively deplete pDCs in our athero-prone mouse model, we lethally irradiated Ldlr−/− mice and reconstituted with BM cells of BDCA2-DTR mice. After 8 weeks, the reconstituted Ldlr−/− mice were fed Western-type diet (WD) and injected with PBS alone or with diphtheria toxin (DT) for the indicated time period as described in the original paper's Figure 4H. Reconstituted mice showed prolonged pDC depletion in spleen by DT injection for 12 weeks (see new Figures 1A and 1B). We also depleted pDCs from the reconstituted mice to test the role of pDCs in already-established atherosclerosis by feeding them WD for 12 weeks but injecting DT only for the last 6 weeks, and observed successful depletion of splenic pDCs (see new Figures 1C and 1D). This additional figure does not affect the conclusion of our paper, and we apologize for any inconvenience.[display presented]

Original languageEnglish
Pages (from-to)886
Number of pages1
JournalCell metabolism
Volume24
Issue number6
DOIs
StatePublished - Dec 13 2016

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