ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I. Modulation of A-type K+ currents

Hui Juan Hu, Kathi S. Glauner, Robert W. Gereau IV

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

The transient outward potassium currents (also known as A-type currents or IA) are important determinants of neuronal excitability. In the brain, IA is modulated by protein kinase C (PKC), protein kinase A (PKA), and extracellular signal-related kinase (ERK), three kinases that have been shown to be critical modulators of nociception. We wanted to determine the effects of these kinases on IA in superficial dorsal horn neurons. Using whole cell recordings from cultured mouse spinal cord superficial dorsal horn neurons, we found that PKC and PKA both inhibit IA in these cells, and that PKC has a tonic inhibitory action on IA. Further, we provide evidence supporting the hypothesis that PKC and PKA do not modulate IA directly, but rather act as upstream activators of ERKs, which modulate IA. These results suggest that ERKs serve as signal integrators in modulation of IA in dorsal horn neurons and that modulation of A-type potassium currents may underlie aspects of central sensitization mediated by PKC, PKA, and ERKs.

Original languageEnglish
Pages (from-to)1671-1679
Number of pages9
JournalJournal of neurophysiology
Volume90
Issue number3
DOIs
StatePublished - Sep 1 2003
Externally publishedYes

Fingerprint Dive into the research topics of 'ERK integrates PKA and PKC signaling in superficial dorsal horn neurons. I. Modulation of A-type K<sup>+</sup> currents'. Together they form a unique fingerprint.

  • Cite this