Erdheim-chester disease involving the bone marrow: A discussion of non-langerhans histiocytic disorders

Alejandro Gru, John L. Frater, Louis P. Dehner, Anjum Hassan, Friederike Kreisel, Mohammad Hussaini, Tudung T. Nguyen

Research output: Contribution to journalReview articlepeer-review

Abstract

Bone marrow involvement by a histiocytic lesion may result in a broad differential diagnosis. Erdheim-Chester disease is a rare aggressive histiocytic proliferation with systemic involvement that frequently causes bone lesions with a characteristic radiographic and clinical presentation. Most patients have bilateral and symmetric sclerotic bone lesions especially involving the long bones of the lower limbs. Extraskeletal involvement of the hypothalamus/ posterior pituitary, central nervous system, orbit, retroperitoneum, skin, lung, kidney, and heart can be seen in half of the cases. Here we report a case of Erdheim-Chester disease, and the clinicopathologic features and the differential diagnosis are discussed. The presented example illustrates the importance of a systematic approach in the evaluation of bone marrow histiocytic lesions.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalPathology Case Reviews
Volume17
Issue number3
DOIs
StatePublished - May 1 2012

Keywords

  • Bone marrow
  • Clinical features
  • Erdheim-Chester disease
  • Histiocytic disorders
  • Pathology

Fingerprint

Dive into the research topics of 'Erdheim-chester disease involving the bone marrow: A discussion of non-langerhans histiocytic disorders'. Together they form a unique fingerprint.

Cite this