Epithelial attachment alters the outcome of Helicobacter pylori infection

Janaki L. Guruge, Per G. Falk, Robin G. Lorenz, Maria Dans, Hans Peter Wirth, Martin J. Blaser, Douglas E. Berg, Jeffrey I. Gordon

Research output: Contribution to journalArticlepeer-review

244 Scopus citations

Abstract

Genetically defined in vivo models are needed to assess the importance of target cell attachment in bacterial pathogenesis. Gastric colonization by Helicobacter pylori in human populations is common and persistent, and has various outcomes including peptic ulcers and cancer. The impact of attachment on the course of infection was examined in transgenic mice expressing a human receptor for H. pylori in their gastric epithelium. Persistent infection by a clinical isolate occurred at comparable microbial densities in transgenic and nontransgenic littermates. However, microbial attachment in transgenic mice resulted in production of autoantibodies to Lewis(x) carbohydrate epitopes shared by bacteria and acid-secreting parietal cells, chronic gastritis, and parietal cell loss. This model should help identify bacterial and host genes that produce attachment-related pathology.

Original languageEnglish
Pages (from-to)3925-3930
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number7
DOIs
StatePublished - Mar 31 1998

Fingerprint

Dive into the research topics of 'Epithelial attachment alters the outcome of Helicobacter pylori infection'. Together they form a unique fingerprint.

Cite this