TY - JOUR
T1 - Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks
AU - Schwedt, Todd J.
AU - Krauss, Melissa J.
AU - Frey, Karen
AU - Gereau IV, Robert W.
N1 - Funding Information:
The authors acknowledge the assistance of Dr Evan Kharasch with the design of this study and for reviewing this manuscript. Dr Kharasch’s work on this project was funded by NIH K24DA00417. This publication was made possible by the following grants: NIH UL1 RR024992, NIH KL2 RR024994, and NIH RO1NS48602.
PY - 2011/1
Y1 - 2011/1
N2 - Objective: To determine if migraineurs have evidence of interictal cutaneous sensitisation. Subjects and methods: Thermal and mechanical pain thresholds in 20 episodic migraineurs, 20 chronic migraineurs, and 20 non-migraine control subjects were compared. Quantitative sensory testing was conducted when subjects had been migraine-free for at least 48 h. Heat, cold and mechanical pain thresholds, and heat and cold pain tolerance thresholds were measured. Results: Thermal pain thresholds and thermal pain tolerance thresholds differed significantly by headache group (P = 0.001). During the interictal period, episodic and chronic migraineurs were more sensitive to thermal stimulation than non-migraine controls. Conclusions: Interictal sensitisation may predispose the migraineur to development of headaches, may be a marker of migraine activity, and a target for treatment.
AB - Objective: To determine if migraineurs have evidence of interictal cutaneous sensitisation. Subjects and methods: Thermal and mechanical pain thresholds in 20 episodic migraineurs, 20 chronic migraineurs, and 20 non-migraine control subjects were compared. Quantitative sensory testing was conducted when subjects had been migraine-free for at least 48 h. Heat, cold and mechanical pain thresholds, and heat and cold pain tolerance thresholds were measured. Results: Thermal pain thresholds and thermal pain tolerance thresholds differed significantly by headache group (P = 0.001). During the interictal period, episodic and chronic migraineurs were more sensitive to thermal stimulation than non-migraine controls. Conclusions: Interictal sensitisation may predispose the migraineur to development of headaches, may be a marker of migraine activity, and a target for treatment.
KW - central sensitisation
KW - cutaneous allodynia
KW - migraine
KW - pain thresholds
KW - quantitative sensory testing
UR - http://www.scopus.com/inward/record.url?scp=79751485839&partnerID=8YFLogxK
U2 - 10.1177/0333102410365108
DO - 10.1177/0333102410365108
M3 - Article
C2 - 20974609
AN - SCOPUS:79751485839
SN - 0333-1024
VL - 31
SP - 6
EP - 12
JO - Cephalalgia
JF - Cephalalgia
IS - 1
ER -