@article{9fd6f3fc4c75402ab0410630d3e36337,
title = "Epigenomic programming in early fetal brain development",
abstract = "Aim: To provide a comprehensive understanding of gene regulatory networks in the developing human brain and a foundation for interpreting pathogenic deregulation. Materials & methods: We generated reference epigenomes and transcriptomes of dissected brain regions and primary neural progenitor cells (NPCs) derived from cortical and ganglionic eminence tissues of four normal human fetuses. Results: Integration of these data across developmental stages revealed a directional increase in active regulatory states, transcription factor activities and gene transcription with developmental stage. Consistent with differences in their biology, NPCs derived from cortical and ganglionic eminence regions contained common, region specific, and gestational week specific regulatory states. Conclusion: We provide a high-resolution regulatory network for NPCs from different brain regions as a comprehensive reference for future studies.",
keywords = "DNA methylation, brain, cortex, enhancer, epigenetics, fetal, ganglionic eminence, gestational week, neural progenitor cells, transcriptional network",
author = "Luolan Li and Maire, {Cecile L.} and Misha Bilenky and Anna{\"i}ck Carles and Alireza Heravi-Moussavi and Chibo Hong and Angela Tam and Baljit Kamoh and Stephanie Cho and Dorothy Cheung and Irene Li and Tina Wong and Nagarajan, {Raman P.} and Mungall, {Andrew J.} and Richard Moore and Ting Wang and Kleinman, {Claudia L.} and Nada Jabado and Jones, {Steven J.M.} and Marra, {Marco A.} and Ligon, {Keith L.} and Costello, {Joseph F.} and Martin Hirst",
note = "Funding Information: the Canadian Epigenetics, Environment and Health Research Consortium Network (CIHR-262119). L Li is supported by a Genome Science and Technology Graduate Program Fellowship, University of British Columbia. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Funding Information: This work was supported with funding provided by the US National Institutes of Health (NIH) Roadmap Epigenomics Program, NIH grant 5U01ES017154-02 and from Genome British Columbia and the Canadian Institutes of Health Research as part of Publisher Copyright: {\textcopyright} 2020 Martin Hirst.",
year = "2020",
month = jun,
doi = "10.2217/epi-2019-0319",
language = "English",
volume = "12",
pages = "1053--1070",
journal = "Epigenomics",
issn = "1750-1911",
number = "12",
}