Epigenomic programming in early fetal brain development

Luolan Li, Cecile L. Maire, Misha Bilenky, Annaïck Carles, Alireza Heravi-Moussavi, Chibo Hong, Angela Tam, Baljit Kamoh, Stephanie Cho, Dorothy Cheung, Irene Li, Tina Wong, Raman P. Nagarajan, Andrew J. Mungall, Richard Moore, Ting Wang, Claudia L. Kleinman, Nada Jabado, Steven J.M. Jones, Marco A. MarraKeith L. Ligon, Joseph F. Costello, Martin Hirst

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Aim: To provide a comprehensive understanding of gene regulatory networks in the developing human brain and a foundation for interpreting pathogenic deregulation. Materials & methods: We generated reference epigenomes and transcriptomes of dissected brain regions and primary neural progenitor cells (NPCs) derived from cortical and ganglionic eminence tissues of four normal human fetuses. Results: Integration of these data across developmental stages revealed a directional increase in active regulatory states, transcription factor activities and gene transcription with developmental stage. Consistent with differences in their biology, NPCs derived from cortical and ganglionic eminence regions contained common, region specific, and gestational week specific regulatory states. Conclusion: We provide a high-resolution regulatory network for NPCs from different brain regions as a comprehensive reference for future studies.

Original languageEnglish
Pages (from-to)1053-1070
Number of pages18
JournalEpigenomics
Volume12
Issue number12
DOIs
StatePublished - Jun 2020

Keywords

  • DNA methylation
  • brain
  • cortex
  • enhancer
  • epigenetics
  • fetal
  • ganglionic eminence
  • gestational week
  • neural progenitor cells
  • transcriptional network

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