Epigenetics of colorectal cancer

Kumar S. Bishnupuri, Manoj K. Mishra

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Common gastrointestinal (GI) cancers, including those of colon/rectum, stomach, pancreas, liver and esophagus account for more than half of the worldwide cancer related deaths. Colorectal cancer (CRC) is the most common GI malignancy diagnosed in both men and women. Although, a significant advancement has occurred towards understanding the multistep process of colorectal carcinogenesis, most of studies and existing therapeutic approaches are primarily based on genetic alterations of the disease. Growing evidences in recent years have now realized the involvement of epigenetic abnormalities along with genetic alterations to be crucial for growth and development of CRC. This chapter is focused on providing basics of human CRC and enumerating epigenetic changes associated with its growth and development, hence provides a better understanding of colorectal carcinogenesis.

Original languageEnglish
Title of host publicationEpigenetic Advancements in Cancer
PublisherSpringer International Publishing
Pages97-121
Number of pages25
ISBN (Electronic)9783319249513
ISBN (Print)9783319249490
DOIs
StatePublished - Jan 1 2016

Keywords

  • CPG island
  • Colorectal cancer
  • Epigenetics
  • Histone modification
  • Hypermethylation

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