Epigenetics and cerebrovascular diseases

C. Soriano-Tárraga; J. Jiménez-Conde; J. Roquer

doi:10.1016/B978-0-12-800226-1.00014-9

Epigenetics and cerebrovascular diseases

C. Soriano-Tárraga
, J. Jiménez-Conde
, J. Roquer

Department of Psychiatry

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Cerebrovascular diseases, and specifically stroke, are heterogeneous multifactorial diseases and are among the leading causes of mortality and long-term disability in the world. Epidemiological data provides evidence for a genetic component to the diseases; however, the epigenetic contribution to stroke is still largely unknown. A lack of heritability has been described in stroke that might be explained by the effect of epigenetic mechanisms that are sequence-independent and might be environmentally induced. In order to better understand the pathogenicity of this complex disease, the influence of environmental factors, and polygenic susceptibility must be determined. This chapter focuses on stroke-related epigenetic mechanisms described to date, especially DNA methylation, and cardiovascular risk factors that modulate the risk of stroke.

Original language	English
Title of host publication	Neuropsychiatric Disorders and Epigenetics
Publisher	Elsevier Inc.
Pages	277-298
Number of pages	22
ISBN (Print)	9780128002261
DOIs	https://doi.org/10.1016/B978-0-12-800226-1.00014-9
State	Published - 2017

Keywords

Cardiovascular risk factors
Cerebrovascular diseases
DNA methylation
Epigenetics
Ischemic stroke

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10.1016/B978-0-12-800226-1.00014-9

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abstract = "Cerebrovascular diseases, and specifically stroke, are heterogeneous multifactorial diseases and are among the leading causes of mortality and long-term disability in the world. Epidemiological data provides evidence for a genetic component to the diseases; however, the epigenetic contribution to stroke is still largely unknown. A lack of heritability has been described in stroke that might be explained by the effect of epigenetic mechanisms that are sequence-independent and might be environmentally induced. In order to better understand the pathogenicity of this complex disease, the influence of environmental factors, and polygenic susceptibility must be determined. This chapter focuses on stroke-related epigenetic mechanisms described to date, especially DNA methylation, and cardiovascular risk factors that modulate the risk of stroke.",

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T1 - Epigenetics and cerebrovascular diseases

AU - Soriano-Tárraga, C.

AU - Jiménez-Conde, J.

AU - Roquer, J.

PY - 2017

Y1 - 2017

N2 - Cerebrovascular diseases, and specifically stroke, are heterogeneous multifactorial diseases and are among the leading causes of mortality and long-term disability in the world. Epidemiological data provides evidence for a genetic component to the diseases; however, the epigenetic contribution to stroke is still largely unknown. A lack of heritability has been described in stroke that might be explained by the effect of epigenetic mechanisms that are sequence-independent and might be environmentally induced. In order to better understand the pathogenicity of this complex disease, the influence of environmental factors, and polygenic susceptibility must be determined. This chapter focuses on stroke-related epigenetic mechanisms described to date, especially DNA methylation, and cardiovascular risk factors that modulate the risk of stroke.

AB - Cerebrovascular diseases, and specifically stroke, are heterogeneous multifactorial diseases and are among the leading causes of mortality and long-term disability in the world. Epidemiological data provides evidence for a genetic component to the diseases; however, the epigenetic contribution to stroke is still largely unknown. A lack of heritability has been described in stroke that might be explained by the effect of epigenetic mechanisms that are sequence-independent and might be environmentally induced. In order to better understand the pathogenicity of this complex disease, the influence of environmental factors, and polygenic susceptibility must be determined. This chapter focuses on stroke-related epigenetic mechanisms described to date, especially DNA methylation, and cardiovascular risk factors that modulate the risk of stroke.

KW - Cardiovascular risk factors

KW - Cerebrovascular diseases

KW - DNA methylation

KW - Epigenetics

KW - Ischemic stroke

UR - https://www.scopus.com/pages/publications/85010015600

U2 - 10.1016/B978-0-12-800226-1.00014-9

DO - 10.1016/B978-0-12-800226-1.00014-9

M3 - Chapter

AN - SCOPUS:85010015600

SN - 9780128002261

SP - 277

EP - 298

BT - Neuropsychiatric Disorders and Epigenetics

PB - Elsevier Inc.

ER -

Epigenetics and cerebrovascular diseases

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Keywords

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