Epigenetic regulation of DLG1, via KAiSO, alters mitotic spindle polarity and promotes intestinal tumorigenesis

Keyphrases

• Cancer Initiation 11%
• Cancer Metastasis 11%
• Cancer Progression 11%
• Cellular Migration 11%
• Crypt 11%
• DLG1 100%
• Epigenetic Reader 11%
• Epigenetic Regulation 100%
• Epigenome 11%
• Gene Expression 11%
• Gene-deficient Mice 11%
• Improved Survival 11%
• In Vivo Analysis 11%
• Intestinal Crypts 33%
• Intestinal Epithelium 11%
• Intestinal Tumorigenesis 100%
• Intestine 22%
• Kaiso 55%
• Min Mice 22%
• Mitotic Spindle 100%
• Mouse Model 11%
• Mutation Rate 11%
• Reader Protein 11%
• Spindle Orientation 22%
• Spindle Polarity 100%
• Spontaneous mutation 11%
• Tumor 11%
• Tumor Burden 11%
• Tumor Suppressor 11%
• Villin 11%

Biochemistry, Genetics and Molecular Biology

• Carcinogenesis 100%
• Cell Migration 33%
• Deficiency 33%
• DLG1 100%
• Epigenetics 100%
• Epigenome 33%
• Gene Expression Profiling 33%
• Mitosis Spindle 100%
• Mouse Model 33%
• Mutation Rate 33%
• Spontaneous Mutation 33%
• Tumor Suppressor Protein 33%
• Tumor Volume 33%
• Upregulation 33%
• Villin 33%

Medicine and Dentistry

• Carcinogenesis 100%
• Cell Migration 33%
• Gene Expression Profiling 33%
• Intestinal Epithelium 33%
• Malignant Neoplasm 33%
• Metastatic Carcinoma 33%
• Mitosis Spindle 100%
• Mutation Rate 33%
• Neoplasm 66%
• Spontaneous Mutation 33%
• Tumor Suppressor Protein 33%
• Upregulation 33%
• Villin 33%