Epigenetic Modifiers Alter Host Cell Transcription to Promote Toxoplasma Infection

Alex Rosenberg, L. David Sibley

Research output: Contribution to journalArticlepeer-review

Abstract

Given the importance of epigenetic modification, pathogens have found a variety of ways to alter chromatin and affect host gene expression. The apicomplexan parasite Toxoplasma gondii expresses two nuclear targeted secreted effectors TgIST and TgNSM that target the activity of host histone deacetylase regulating corepressor complexes NuRD and NCoR/SMRT, respectively. TgIST and TgNSM are crucial for blocking the host interferon response protecting both the acute and latent stages of the infection. T. gondii represents a unique model organism to study the significance of epigenetic modifications in the regulation of interferon responses and other transcriptional responses at the interface of host-pathogen interaction.

Original languageEnglish
Pages (from-to)411-413
JournalACS Infectious Diseases
Volume8
Issue number3
DOIs
StatePublished - Mar 11 2022

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