Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder

Monica Uddin; Andrew Ratanatharathorn; Don Armstrong; Pei Fen Kuan; Allison E. Aiello; Evelyn J. Bromet; Sandro Galea; Karestan C. Koenen; Benjamin Luft; Kerry J. Ressler; Derek E. Wildman; Caroline M. Nievergelt; Alicia Smith

doi:10.2217/epi-2018-0049

Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder

Monica Uddin
, Andrew Ratanatharathorn
, Don Armstrong
, Pei Fen Kuan
, Allison E. Aiello
, Evelyn J. Bromet
, Sandro Galea
, Karestan C. Koenen
, Benjamin Luft
, Kerry J. Ressler
, Derek E. Wildman
, Caroline M. Nievergelt
, Alicia Smith

Washington University in St. Louis

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Aim: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD. Materials & methods: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium. Results: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098). Conclusion: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.

Original language	English
Pages (from-to)	1585-1601
Number of pages	17
Journal	Epigenomics
Volume	10
Issue number	12
DOIs	https://doi.org/10.2217/epi-2018-0049
State	Published - Dec 2018

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Uddin, M., Ratanatharathorn, A., Armstrong, D., Kuan, P. F., Aiello, A. E., Bromet, E. J., Galea, S., Koenen, K. C., Luft, B., Ressler, K. J., Wildman, D. E., Nievergelt, C. M., & Smith, A. (2018). Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder. Epigenomics, 10(12), 1585-1601. https://doi.org/10.2217/epi-2018-0049

@article{35c524eaa91e48a79439decfbed6c725,

title = "Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder",

abstract = "Aim: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD. Materials \& methods: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium. Results: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098). Conclusion: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.",

author = "Monica Uddin and Andrew Ratanatharathorn and Don Armstrong and Kuan, \{Pei Fen\} and Aiello, \{Allison E.\} and Bromet, \{Evelyn J.\} and Sandro Galea and Koenen, \{Karestan C.\} and Benjamin Luft and Ressler, \{Kerry J.\} and Wildman, \{Derek E.\} and Nievergelt, \{Caroline M.\} and Alicia Smith",

note = "Publisher Copyright: {\textcopyright} 2018 2018 Future Medicine Ltd.",

year = "2018",

month = dec,

doi = "10.2217/epi-2018-0049",

language = "English",

volume = "10",

pages = "1585--1601",

journal = "Epigenomics",

issn = "1750-1911",

number = "12",

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Uddin, M, Ratanatharathorn, A, Armstrong, D, Kuan, PF, Aiello, AE, Bromet, EJ, Galea, S, Koenen, KC, Luft, B, Ressler, KJ, Wildman, DE, Nievergelt, CM & Smith, A 2018, 'Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder', Epigenomics, vol. 10, no. 12, pp. 1585-1601. https://doi.org/10.2217/epi-2018-0049

TY - JOUR

T1 - Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder

AU - Uddin, Monica

AU - Ratanatharathorn, Andrew

AU - Armstrong, Don

AU - Kuan, Pei Fen

AU - Aiello, Allison E.

AU - Bromet, Evelyn J.

AU - Galea, Sandro

AU - Koenen, Karestan C.

AU - Luft, Benjamin

AU - Ressler, Kerry J.

AU - Wildman, Derek E.

AU - Nievergelt, Caroline M.

AU - Smith, Alicia

PY - 2018/12

Y1 - 2018/12

N2 - Aim: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD. Materials & methods: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium. Results: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098). Conclusion: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.

AB - Aim: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD. Materials & methods: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium. Results: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098). Conclusion: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.

UR - https://www.scopus.com/pages/publications/85058077061

U2 - 10.2217/epi-2018-0049

DO - 10.2217/epi-2018-0049

M3 - Article

C2 - 30456986

AN - SCOPUS:85058077061

SN - 1750-1911

VL - 10

SP - 1585

EP - 1601

JO - Epigenomics

JF - Epigenomics

IS - 12

ER -

Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder

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