Epigenetic and microRNA regulation during osteoarthritis development

Di Chen; Jie Shen; Tianqian Hui

doi:10.12688/f1000research.6548.1

Epigenetic and microRNA regulation during osteoarthritis development

Di Chen, Jie Shen, Tianqian Hui

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Osteoarthritis (OA) is a common degenerative joint disease, the pathological mechanism of which is currently unknown. Genetic alteration is one of the key contributing factors for OA pathology. Recent evidence suggests that epigenetic and microRNA regulation of critical genes may contribute to OA development. In this article, we review the epigenetic and microRNA regulations of genes related to OA development. Potential therapeutic strategies may be developed on the basis of novel findings.

Original language	English
Article number	1092
Journal	F1000Research
Volume	4
DOIs	https://doi.org/10.12688/f1000research.6548.1
State	Published - 2015

Access to Document

10.12688/f1000research.6548.1

Cite this

@article{b9070fa341354a05962512484d362d2e,

title = "Epigenetic and microRNA regulation during osteoarthritis development",

abstract = "Osteoarthritis (OA) is a common degenerative joint disease, the pathological mechanism of which is currently unknown. Genetic alteration is one of the key contributing factors for OA pathology. Recent evidence suggests that epigenetic and microRNA regulation of critical genes may contribute to OA development. In this article, we review the epigenetic and microRNA regulations of genes related to OA development. Potential therapeutic strategies may be developed on the basis of novel findings.",

author = "Di Chen and Jie Shen and Tianqian Hui",

note = "Publisher Copyright: {\textcopyright} 2015 Chen D et al.",

year = "2015",

doi = "10.12688/f1000research.6548.1",

language = "English",

volume = "4",

journal = "F1000Research",

issn = "2046-1402",

}

TY - JOUR

T1 - Epigenetic and microRNA regulation during osteoarthritis development

AU - Chen, Di

AU - Shen, Jie

AU - Hui, Tianqian

PY - 2015

Y1 - 2015

N2 - Osteoarthritis (OA) is a common degenerative joint disease, the pathological mechanism of which is currently unknown. Genetic alteration is one of the key contributing factors for OA pathology. Recent evidence suggests that epigenetic and microRNA regulation of critical genes may contribute to OA development. In this article, we review the epigenetic and microRNA regulations of genes related to OA development. Potential therapeutic strategies may be developed on the basis of novel findings.

AB - Osteoarthritis (OA) is a common degenerative joint disease, the pathological mechanism of which is currently unknown. Genetic alteration is one of the key contributing factors for OA pathology. Recent evidence suggests that epigenetic and microRNA regulation of critical genes may contribute to OA development. In this article, we review the epigenetic and microRNA regulations of genes related to OA development. Potential therapeutic strategies may be developed on the basis of novel findings.

UR - http://www.scopus.com/inward/record.url?scp=84964470822&partnerID=8YFLogxK

U2 - 10.12688/f1000research.6548.1

DO - 10.12688/f1000research.6548.1

M3 - Review article

AN - SCOPUS:84964470822

SN - 2046-1402

VL - 4

JO - F1000Research

JF - F1000Research

M1 - 1092

ER -

Epigenetic and microRNA regulation during osteoarthritis development

Abstract

Access to Document

Other files and links

Fingerprint

Cite this