Epidemiology and Prevention of HPV-Associated Squamous Cell Carcinoma

Sophie P. Gerndt, Jose P. Zevallos

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: This review aims to provide an up-to-date overview of epidemiology and prevention in HPV-associated cancer focused in oropharyngeal cancer (OPC). Recent Findings:: Current epidemiologic trends suggest that HPV-positive OPC remains a male epidemic; however, latest changes demonstrate an increase in incidence of the older population.Oral HPV infection precedes incidence of OPC; however, the time after infection at which carcinogenesis begins is still unknown. Persistent infection may lead to OPC.HPV vaccination decreases oral HPV prevalence. In addition, OPC was recently added as an indication for this vaccine.Screening for HPV-positive OPC is currently not justified. Identification of high-risk individuals could be a key factor to determine future prevention strategies. Summary: The unfilled knowledge gaps regarding natural history of this disease complicate the future application of prevention strategies. With the emerging changes in epidemiologic trends, the development of efficient prevention strategies is crucial.

Original languageEnglish
Pages (from-to)58-67
JournalCurrent Otorhinolaryngology Reports
Issue number1
StatePublished - Mar 2022


  • Epidemiology
  • HPV vaccine
  • HPV-positive OPC
  • Human papillomavirus
  • Oropharyngeal cancer
  • Prevention


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