TY - JOUR
T1 - Epidemiology and persistence of rhinovirus in pediatric lung transplantation
AU - Ammerman, Evan
AU - Sweet, Stuart C.
AU - Storch, Gregory A.
AU - Buller, Richard S.
AU - Mason, Sheila
AU - Conrad, Carol
AU - Hayes, Don
AU - Faro, Albert
AU - Goldfarb, Samuel B.
AU - Melicoff, Ernestina
AU - Schecter, Marc
AU - Visner, Gary
AU - Heeger, Peter S.
AU - Mohanakumar, Thalachallour
AU - Williams, Nikki
AU - Danziger-Isakov, Lara
N1 - Funding Information:
This research was performed as a project of the Clinical Trials in Organ Transplantation in Children, a collaborative clinical research project headquartered at the National Institute of Allergy and Infectious Diseases. The work was supported by Grant U01 AI077810 “Viral Triggers of Alloimmunity and Autoimmunity in Pediatric Lung Transplantation” from the Division of Allergy, Immunology and Transplantation of the National Institutes of Health. 33
Funding Information:
This research was performed as a project of the Clinical Trials in Organ Transplantation in Children, a collaborative clinical research project headquartered at the National Institute of Allergy and Infectious Diseases. The work was supported by Grant U01 AI077810 ?Viral Triggers of Alloimmunity and Autoimmunity in Pediatric Lung Transplantation? from the Division of Allergy, Immunology and Transplantation of the National Institutes of Health.33
Publisher Copyright:
© 2020 Wiley Periodicals LLC
PY - 2020/12
Y1 - 2020/12
N2 - Background: Infection with rhinovirus (HRV) occurs following pediatric lung transplantation. Prospective studies documenting frequencies, persistence, and progression of HRV in this at-risk population are lacking. Methods: In the Clinical Trials in Organ Transplant in Children prospective observational study, we followed 61 lung transplant recipients for 2 years. We quantified molecular subtypes of HRV in serially collected nasopharyngeal (NP) and bronchoalveolar lavage (BAL) samples and correlated them with clinical characteristics. Results: We identified 135 community-acquired respiratory infections (CARV) from 397 BAL and 480 NP samples. We detected 93 HRV events in 42 (68.8%) patients, 22 of which (23.4%) were symptomatic. HRV events were contiguous with different genotypes identified in 23 cases, but symptoms were not preferentially associated with any particular species. Nine (9.7%) HRV events persisted over multiple successive samples for a median of 36 days (range 18-408 days). Three persistent HRV were symptomatic. When we serially measured forced expiratory volume in one second (FEV1) in 23 subjects with events, we did not observe significant decreases in lung function over 12 months post-HRV. Conclusion: In conjunction with our previous reports, our prospectively collected data indicate that molecularly heterogeneous HRV infections occur commonly following pediatric lung transplantation, but these infections do not negatively impact clinical outcomes.
AB - Background: Infection with rhinovirus (HRV) occurs following pediatric lung transplantation. Prospective studies documenting frequencies, persistence, and progression of HRV in this at-risk population are lacking. Methods: In the Clinical Trials in Organ Transplant in Children prospective observational study, we followed 61 lung transplant recipients for 2 years. We quantified molecular subtypes of HRV in serially collected nasopharyngeal (NP) and bronchoalveolar lavage (BAL) samples and correlated them with clinical characteristics. Results: We identified 135 community-acquired respiratory infections (CARV) from 397 BAL and 480 NP samples. We detected 93 HRV events in 42 (68.8%) patients, 22 of which (23.4%) were symptomatic. HRV events were contiguous with different genotypes identified in 23 cases, but symptoms were not preferentially associated with any particular species. Nine (9.7%) HRV events persisted over multiple successive samples for a median of 36 days (range 18-408 days). Three persistent HRV were symptomatic. When we serially measured forced expiratory volume in one second (FEV1) in 23 subjects with events, we did not observe significant decreases in lung function over 12 months post-HRV. Conclusion: In conjunction with our previous reports, our prospectively collected data indicate that molecularly heterogeneous HRV infections occur commonly following pediatric lung transplantation, but these infections do not negatively impact clinical outcomes.
KW - community-acquired respiratory virus (CARV)
KW - forced expiratory volume (FEV1)
KW - human rhinovirus (HRV)
KW - lung transplantation
KW - pediatrics
UR - http://www.scopus.com/inward/record.url?scp=85088805788&partnerID=8YFLogxK
U2 - 10.1111/tid.13422
DO - 10.1111/tid.13422
M3 - Article
C2 - 32686323
AN - SCOPUS:85088805788
SN - 1398-2273
VL - 22
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
IS - 6
M1 - e13422
ER -