TY - JOUR
T1 - Epidemiology and neuropsychiatric manifestations of Young Onset Parkinson's Disease in the United States
AU - Willis, A. W.
AU - Schootman, M.
AU - Kung, N.
AU - Racette, B. A.
N1 - Funding Information:
Dr. Schootman receives support from NIH [ 5R01CA109675-03 (PI), NIH 5R01CA137750-02 (PI), NIH 5R01CA112159-05 (PI)].
Funding Information:
This work was supported by the National Institute of Neurological Disorders and Stroke at the National Institutes of Health ( 5T32NS007205-27 ); the National Center for Research Resources and National Institutes of Health Roadmap for Medical Research ( UL1RR024992 , KL2RR024994 ); National Institute for Environmental Health Sciences at the National Institutes of Health ( K24ES017765 ); the St. Louis Chapter of the American Parkinson Disease Association ; the American Parkinson Disease Association , Walter and Connie Donius ; and the Robert Renschen Fund .
Funding Information:
Dr. Willis receives research support from the NIH [ KL2 RR024994 , R01 ES013743-01A2 ], the American Parkinson Disease Association, St. Louis Chapter, Walter and Connie Donius, The Robert Renschen Fund.
Funding Information:
Dr. Racette received research support from Teva (PI), Eisai (PI), and Solvay (PI); receives research support from Schwarz (PI), Solstice (PI), Eisai (PI), Allergan (PI), and Neurogen (PI); received government research support from NIH [ 5R01 NS037167-10 (PI-Foroud, T)]; receives research support from NIH [ U10 NS44455 (PI), R01 ES013743-01A2 (PI), P42 ES04696 (PI-Checkoway, H), K24 NS060825 (PI), R21 ES017504 (PI)]; received research support from BJHF/ICTS [“Neuropathology of Chronic Manganese Exposure” (PI)]; and received research support from received research support from the Michael J. Fox Foundation .
PY - 2013/2
Y1 - 2013/2
N2 - Background: To determine the demographic distribution of Young Onset Parkinson's Disease (YOPD) in the United States and to quantify the burden of neuropsychiatric disease manifestations. Methods: Cross sectional study of 3,459,986 disabled Americans, aged 30-54, who were receiving Medicare benefits in the year 2005. We calculated race and sex distributions of YOPD and used logistic regression to compare the likelihood of common and uncommon psychiatric disorders between beneficiaries with YOPD and the general disability beneficiary population, adjusting for race, age, and sex. Results: We identified 14,354 Medicare beneficiaries with YOPD (prevalence = 414.9 per 100,000 disabled Americans). White men comprised the majority of cases (48.9%), followed by White women (34.7%), Black men (6.8%), Black women (5.0%), Hispanic men (2.4%), and Hispanic women (1.2%). Asian men (0.6%) and Asian women (0.4%) were the least common race-sex pairs with a YOPD diagnosis in this population (chi square, p < 0.001). Compared to the general population of medically disabled Americans, those with YOPD were more likely to receive medical care for depression (OR: 1.89, 1.83-1.95), dementia (OR: 7.73, 7.38-8.09), substance abuse/dependence (OR: 3.00, 2.99-3.01), and were more likely to be hospitalized for psychosis (OR: 3.36, 3.19-3.53), personality/impulse control disorders (OR: 4.56, 3.28-6.34), and psychosocial dysfunction (OR: 3.85, 2.89-5.14). Conclusions: Young Onset Parkinson's Disease is most common among white males in our study population. Psychiatric illness, addiction, and cognitive impairment are more common in YOPD than in the general population of disabled Medicare beneficiaries. These may be key disabling factors in YOPD.
AB - Background: To determine the demographic distribution of Young Onset Parkinson's Disease (YOPD) in the United States and to quantify the burden of neuropsychiatric disease manifestations. Methods: Cross sectional study of 3,459,986 disabled Americans, aged 30-54, who were receiving Medicare benefits in the year 2005. We calculated race and sex distributions of YOPD and used logistic regression to compare the likelihood of common and uncommon psychiatric disorders between beneficiaries with YOPD and the general disability beneficiary population, adjusting for race, age, and sex. Results: We identified 14,354 Medicare beneficiaries with YOPD (prevalence = 414.9 per 100,000 disabled Americans). White men comprised the majority of cases (48.9%), followed by White women (34.7%), Black men (6.8%), Black women (5.0%), Hispanic men (2.4%), and Hispanic women (1.2%). Asian men (0.6%) and Asian women (0.4%) were the least common race-sex pairs with a YOPD diagnosis in this population (chi square, p < 0.001). Compared to the general population of medically disabled Americans, those with YOPD were more likely to receive medical care for depression (OR: 1.89, 1.83-1.95), dementia (OR: 7.73, 7.38-8.09), substance abuse/dependence (OR: 3.00, 2.99-3.01), and were more likely to be hospitalized for psychosis (OR: 3.36, 3.19-3.53), personality/impulse control disorders (OR: 4.56, 3.28-6.34), and psychosocial dysfunction (OR: 3.85, 2.89-5.14). Conclusions: Young Onset Parkinson's Disease is most common among white males in our study population. Psychiatric illness, addiction, and cognitive impairment are more common in YOPD than in the general population of disabled Medicare beneficiaries. These may be key disabling factors in YOPD.
KW - Addiction
KW - Dementia
KW - Medicare
KW - Psychiatry
KW - Young Onset Parkinson's Disease
UR - http://www.scopus.com/inward/record.url?scp=84873736288&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2012.09.014
DO - 10.1016/j.parkreldis.2012.09.014
M3 - Article
C2 - 23083512
AN - SCOPUS:84873736288
SN - 1353-8020
VL - 19
SP - 202
EP - 206
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
IS - 2
ER -