Eosinophilic granuloma of the sacrum treated with radiation therapy: A case report

David B. Bumpass; Andrew Park; Kirk T. Hill; Jiayi Huang; Michael V. Friedman; Lukas P. Zebala

doi:10.1016/j.spinee.2015.09.022

Eosinophilic granuloma of the sacrum treated with radiation therapy: A case report

David B. Bumpass, Andrew Park, Kirk T. Hill, Jiayi Huang, Michael V. Friedman, Lukas P. Zebala

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background Context Eosinophilic granulomas (EGs) of the sacrum have been reported in fewer than 10 patients. Treatment algorithms for these tumors remain poorly defined; there are no reports of treating solitary sacral EG with radiation therapy (RT). Purpose This study aimed to describe the presentation, treatment, and outcome of sacral EG in an adult patient with intractable pain and radiculopathy, treated in a novel fashion with RT. Study Design/Setting The study design was a case report from a tertiary cancer referral center. Methods Patient records, imaging, and pathology were reviewed. Results A 35-year-old man received 20 Gy of radiation to his S1 EG lesion. He subsequently developed vertebra plana of S1 causing symptomatic L5-S1 stenosis, but 15 months after RT treatment was free of pain or tumor recurrence. Conclusion Radiation therapy is an effective treatment option for sacral EG causing severe axial pain and neural impingement.

Original language	English
Pages (from-to)	e53-e57
Journal	Spine Journal
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/j.spinee.2015.09.022
State	Published - Jan 1 2016

Keywords

Benign bone tumor
Eosinophilic granuloma
Langerhans cell histiocytosis
Radiation therapy
Sacrum
Spine tumor

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10.1016/j.spinee.2015.09.022

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@article{3726cf7afa1c415d8a89e2017b5d686b,

title = "Eosinophilic granuloma of the sacrum treated with radiation therapy: A case report",

abstract = "Background Context Eosinophilic granulomas (EGs) of the sacrum have been reported in fewer than 10 patients. Treatment algorithms for these tumors remain poorly defined; there are no reports of treating solitary sacral EG with radiation therapy (RT). Purpose This study aimed to describe the presentation, treatment, and outcome of sacral EG in an adult patient with intractable pain and radiculopathy, treated in a novel fashion with RT. Study Design/Setting The study design was a case report from a tertiary cancer referral center. Methods Patient records, imaging, and pathology were reviewed. Results A 35-year-old man received 20 Gy of radiation to his S1 EG lesion. He subsequently developed vertebra plana of S1 causing symptomatic L5-S1 stenosis, but 15 months after RT treatment was free of pain or tumor recurrence. Conclusion Radiation therapy is an effective treatment option for sacral EG causing severe axial pain and neural impingement.",

keywords = "Benign bone tumor, Eosinophilic granuloma, Langerhans cell histiocytosis, Radiation therapy, Sacrum, Spine tumor",

author = "Bumpass, {David B.} and Andrew Park and Hill, {Kirk T.} and Jiayi Huang and Friedman, {Michael V.} and Zebala, {Lukas P.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2016",

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day = "1",

doi = "10.1016/j.spinee.2015.09.022",

language = "English",

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T1 - Eosinophilic granuloma of the sacrum treated with radiation therapy

T2 - A case report

AU - Bumpass, David B.

AU - Park, Andrew

AU - Hill, Kirk T.

AU - Huang, Jiayi

AU - Friedman, Michael V.

AU - Zebala, Lukas P.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background Context Eosinophilic granulomas (EGs) of the sacrum have been reported in fewer than 10 patients. Treatment algorithms for these tumors remain poorly defined; there are no reports of treating solitary sacral EG with radiation therapy (RT). Purpose This study aimed to describe the presentation, treatment, and outcome of sacral EG in an adult patient with intractable pain and radiculopathy, treated in a novel fashion with RT. Study Design/Setting The study design was a case report from a tertiary cancer referral center. Methods Patient records, imaging, and pathology were reviewed. Results A 35-year-old man received 20 Gy of radiation to his S1 EG lesion. He subsequently developed vertebra plana of S1 causing symptomatic L5-S1 stenosis, but 15 months after RT treatment was free of pain or tumor recurrence. Conclusion Radiation therapy is an effective treatment option for sacral EG causing severe axial pain and neural impingement.

AB - Background Context Eosinophilic granulomas (EGs) of the sacrum have been reported in fewer than 10 patients. Treatment algorithms for these tumors remain poorly defined; there are no reports of treating solitary sacral EG with radiation therapy (RT). Purpose This study aimed to describe the presentation, treatment, and outcome of sacral EG in an adult patient with intractable pain and radiculopathy, treated in a novel fashion with RT. Study Design/Setting The study design was a case report from a tertiary cancer referral center. Methods Patient records, imaging, and pathology were reviewed. Results A 35-year-old man received 20 Gy of radiation to his S1 EG lesion. He subsequently developed vertebra plana of S1 causing symptomatic L5-S1 stenosis, but 15 months after RT treatment was free of pain or tumor recurrence. Conclusion Radiation therapy is an effective treatment option for sacral EG causing severe axial pain and neural impingement.

KW - Benign bone tumor

KW - Eosinophilic granuloma

KW - Langerhans cell histiocytosis

KW - Radiation therapy

KW - Sacrum

KW - Spine tumor

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SP - e53-e57

JO - Spine Journal

JF - Spine Journal

IS - 1

ER -

Eosinophilic granuloma of the sacrum treated with radiation therapy: A case report

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Keywords

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