@article{abd71ca8e3d14da69297ef2638805405,
title = "Eosinophilic Asthma",
abstract = "Asthma endotypes are constantly evolving. Currently, there are no universally accepted criteria to define endotypes. The TH2-high endotype can have either allergic or nonallergic underpinnings and is typically characterized by some degree of eosinophilic airway inflammation. Unbiased clustering analyses have led to the identification of pediatric and adult phenotypes characterized by TH2 inflammation and associated endotypes with eosinophilic inflammation. Aspirin-exacerbated respiratory disease has also long been recognized as a unique asthma phenotype. An approach to identify these groups with biomarkers and subsequently choose a targeted therapeutic modality, particularly in severe disease requiring biologic agents, is outlined.",
keywords = "Aspirin-exacerbated respiratory disease, Asthma, Endotypes, Eosinophils",
author = "Nelson, {Ryan K.} and Andrew Bush and Jeffrey Stokes and Parameswaran Nair and Praveen Akuthota",
note = "Funding Information: Conflicts of interest: P. Akuthota has received research support from the National Institutes of Health; has received research support and consultancy fees from and is on the advisory board for AstraZeneca and GlaxoSmithKline; has received consultancy fees from Ambrx; receives royalties from UpToDate; and has received honoraria from WebMD/Medscape, AHK, and Prime CME. P. Nair has received investigator-initiated study grants from AstraZeneca, Sanofi, Methapharm, Roche, Boehringer Ingelheim, and Teva; and has received honoraria for lectures and scientific advisory boards from Teva, Sanofi, AstraZeneca, Merck, Novartis, Roche, Equillium, Knopp, and Theravance. The rest of the authors declare that they have no relevant conflicts of interest,. Publisher Copyright: {\textcopyright} 2019 American Academy of Allergy, Asthma & Immunology",
year = "2020",
month = feb,
doi = "10.1016/j.jaip.2019.11.024",
language = "English",
volume = "8",
pages = "465--473",
journal = "Journal of Allergy and Clinical Immunology: In Practice",
issn = "2213-2198",
number = "2",
}