Eosinophilic Asthma

Ryan K. Nelson, Andrew Bush, Jeffrey Stokes, Parameswaran Nair, Praveen Akuthota

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Asthma endotypes are constantly evolving. Currently, there are no universally accepted criteria to define endotypes. The TH2-high endotype can have either allergic or nonallergic underpinnings and is typically characterized by some degree of eosinophilic airway inflammation. Unbiased clustering analyses have led to the identification of pediatric and adult phenotypes characterized by TH2 inflammation and associated endotypes with eosinophilic inflammation. Aspirin-exacerbated respiratory disease has also long been recognized as a unique asthma phenotype. An approach to identify these groups with biomarkers and subsequently choose a targeted therapeutic modality, particularly in severe disease requiring biologic agents, is outlined.

Original languageEnglish
Pages (from-to)465-473
Number of pages9
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume8
Issue number2
DOIs
StatePublished - Feb 2020

Keywords

  • Aspirin-exacerbated respiratory disease
  • Asthma
  • Endotypes
  • Eosinophils

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