Eosinophilic Asthma

Ryan K. Nelson; Andrew Bush; Jeffrey Stokes; Parameswaran Nair; Praveen Akuthota

doi:10.1016/j.jaip.2019.11.024

Eosinophilic Asthma

Ryan K. Nelson, Andrew Bush, Jeffrey Stokes, Parameswaran Nair, Praveen Akuthota

Division of Allergy & Pulmonary Medicine

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Asthma endotypes are constantly evolving. Currently, there are no universally accepted criteria to define endotypes. The T_H2-high endotype can have either allergic or nonallergic underpinnings and is typically characterized by some degree of eosinophilic airway inflammation. Unbiased clustering analyses have led to the identification of pediatric and adult phenotypes characterized by T_H2 inflammation and associated endotypes with eosinophilic inflammation. Aspirin-exacerbated respiratory disease has also long been recognized as a unique asthma phenotype. An approach to identify these groups with biomarkers and subsequently choose a targeted therapeutic modality, particularly in severe disease requiring biologic agents, is outlined.

Original language	English
Pages (from-to)	465-473
Number of pages	9
Journal	Journal of Allergy and Clinical Immunology: In Practice
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/j.jaip.2019.11.024
State	Published - Feb 2020

Keywords

Aspirin-exacerbated respiratory disease
Asthma
Endotypes
Eosinophils

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10.1016/j.jaip.2019.11.024

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title = "Eosinophilic Asthma",

abstract = "Asthma endotypes are constantly evolving. Currently, there are no universally accepted criteria to define endotypes. The TH2-high endotype can have either allergic or nonallergic underpinnings and is typically characterized by some degree of eosinophilic airway inflammation. Unbiased clustering analyses have led to the identification of pediatric and adult phenotypes characterized by TH2 inflammation and associated endotypes with eosinophilic inflammation. Aspirin-exacerbated respiratory disease has also long been recognized as a unique asthma phenotype. An approach to identify these groups with biomarkers and subsequently choose a targeted therapeutic modality, particularly in severe disease requiring biologic agents, is outlined.",

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author = "Nelson, {Ryan K.} and Andrew Bush and Jeffrey Stokes and Parameswaran Nair and Praveen Akuthota",

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AU - Bush, Andrew

AU - Stokes, Jeffrey

AU - Nair, Parameswaran

AU - Akuthota, Praveen

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Y1 - 2020/2

N2 - Asthma endotypes are constantly evolving. Currently, there are no universally accepted criteria to define endotypes. The TH2-high endotype can have either allergic or nonallergic underpinnings and is typically characterized by some degree of eosinophilic airway inflammation. Unbiased clustering analyses have led to the identification of pediatric and adult phenotypes characterized by TH2 inflammation and associated endotypes with eosinophilic inflammation. Aspirin-exacerbated respiratory disease has also long been recognized as a unique asthma phenotype. An approach to identify these groups with biomarkers and subsequently choose a targeted therapeutic modality, particularly in severe disease requiring biologic agents, is outlined.

AB - Asthma endotypes are constantly evolving. Currently, there are no universally accepted criteria to define endotypes. The TH2-high endotype can have either allergic or nonallergic underpinnings and is typically characterized by some degree of eosinophilic airway inflammation. Unbiased clustering analyses have led to the identification of pediatric and adult phenotypes characterized by TH2 inflammation and associated endotypes with eosinophilic inflammation. Aspirin-exacerbated respiratory disease has also long been recognized as a unique asthma phenotype. An approach to identify these groups with biomarkers and subsequently choose a targeted therapeutic modality, particularly in severe disease requiring biologic agents, is outlined.

KW - Aspirin-exacerbated respiratory disease

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KW - Endotypes

KW - Eosinophils

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JO - Journal of Allergy and Clinical Immunology: In Practice

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ER -

Eosinophilic Asthma

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Keywords

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