Enzymology and molecular biology of alkaloid biosynthesis

T. M. Kutchan; H. Dittrich; D. Bracher; M. H. Zenk

doi:10.1016/S0040-4020(01)86487-5

Enzymology and molecular biology of alkaloid biosynthesis

T. M. Kutchan
, H. Dittrich
, D. Bracher
, M. H. Zenk

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The biosynthetic pathways leading to the benzophenanthridine alkaloid, sanguinarine, and the indole alkaloids, ajmalicine and ajmaline, have been solved at the level of the individual enzymes involved. The cDNA for two of the key enzymes has been cloned and the enzymes subsequently actively expressed in heterologous organisms.

Original language	English
Pages (from-to)	5945-5954
Number of pages	10
Journal	Tetrahedron
Volume	47
Issue number	31
DOIs	https://doi.org/10.1016/S0040-4020(01)86487-5
State	Published - Jul 29 1991

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10.1016/S0040-4020(01)86487-5

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title = "Enzymology and molecular biology of alkaloid biosynthesis",

abstract = "The biosynthetic pathways leading to the benzophenanthridine alkaloid, sanguinarine, and the indole alkaloids, ajmalicine and ajmaline, have been solved at the level of the individual enzymes involved. The cDNA for two of the key enzymes has been cloned and the enzymes subsequently actively expressed in heterologous organisms.",

author = "Kutchan, \{T. M.\} and H. Dittrich and D. Bracher and Zenk, \{M. H.\}",

note = "Funding Information: by the Bundesministefri lr Forschungu nd Technoiogie,B onn and by Fonds der ChemischenI ndustrie.",

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AU - Kutchan, T. M.

AU - Dittrich, H.

AU - Bracher, D.

AU - Zenk, M. H.

N1 - Funding Information: by the Bundesministefri lr Forschungu nd Technoiogie,B onn and by Fonds der ChemischenI ndustrie.

PY - 1991/7/29

Y1 - 1991/7/29

N2 - The biosynthetic pathways leading to the benzophenanthridine alkaloid, sanguinarine, and the indole alkaloids, ajmalicine and ajmaline, have been solved at the level of the individual enzymes involved. The cDNA for two of the key enzymes has been cloned and the enzymes subsequently actively expressed in heterologous organisms.

AB - The biosynthetic pathways leading to the benzophenanthridine alkaloid, sanguinarine, and the indole alkaloids, ajmalicine and ajmaline, have been solved at the level of the individual enzymes involved. The cDNA for two of the key enzymes has been cloned and the enzymes subsequently actively expressed in heterologous organisms.

UR - https://www.scopus.com/pages/publications/0025878733

U2 - 10.1016/S0040-4020(01)86487-5

DO - 10.1016/S0040-4020(01)86487-5

M3 - Article

AN - SCOPUS:0025878733

SN - 0040-4020

VL - 47

SP - 5945

EP - 5954

JO - Tetrahedron

JF - Tetrahedron

IS - 31

ER -

Enzymology and molecular biology of alkaloid biosynthesis

Abstract

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