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Enzyme replacement prevents enamel defects in hypophosphatasia mice
Manisha C. Yadav
, Rodrigo Cardoso De Oliveira
, Brian L. Foster
, Hanson Fong
, Esther Cory
, Sonoko Narisawa
, Robert L. Sah
, Martha Somerman
, Michael P. Whyte
, José Luis Millán
Division of Bone & Mineral Diseases
Institute of Clinical and Translational Sciences (ICTS)
Research output
:
Contribution to journal
›
Article
›
peer-review
86
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Scopus citations
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Keyphrases
Isozymes
100%
Hypophosphatasia
100%
Alkaline Phosphatase
100%
Enzyme Replacement Therapy
100%
Enamel Defects
100%
Alpl
33%
Rickets
22%
Immunohistochemistry
11%
Seizure
11%
Alkaline Phosphatase Activity
11%
Osteomalacia
11%
Gain-of-function mutation
11%
Healthy Mice
11%
Rod-like
11%
Inborn Errors of Metabolism
11%
Human Tissue
11%
Vitamin B6
11%
Phenocopy
11%
Subcutaneous Injection
11%
Enamel
11%
Stage-specific Expression
11%
Scanning Electron Microscopy Analysis
11%
Incisor
11%
Dental Defects
11%
Spatiotemporal Expression
11%
Ameloblast
11%
Acellular Cementum
11%
Dentin Mineralization
11%
Mineral Targeting
11%
Mouse Incisor
11%
Enamel Organ
11%
Mouse Molar
11%
Enamel Mineralization
11%
Medicine and Dentistry
Enzyme Replacement Therapy
100%
Alkaline Phosphatase
100%
Hypophosphatasia
100%
Enamel Defects
100%
Isoenzyme
90%
Mineralization
30%
Rickets
20%
Incisor
20%
Immunohistochemistry
10%
Epileptic Seizure
10%
Loss of Function Mutation
10%
Scanning Electron Microscopy
10%
Osteomalacia
10%
Human Tissue
10%
Inborn Error of Metabolism
10%
Subcutaneous Injection
10%
Dentin
10%
Pyridoxine
10%
Ameloblast
10%
Cementum
10%
Enamel Organ
10%
Biochemistry, Genetics and Molecular Biology
Enzyme
100%
Alkaline Phosphatase
100%
Isoenzyme
90%
Mineralization
30%
Rickets
20%
Loss of Function Mutation
10%
Osteomalacia
10%
Electron Microscopy
10%
Scanning Electron Microscopy
10%
Inborn Error of Metabolism
10%
Phenocopy
10%
Ameloblast
10%
Pyridoxine
10%
Vitamin B6
10%
Deficiency
10%