TY - JOUR
T1 - Environmental risk factors for REM sleep behavior disorder
T2 - A multicenter case-control study
AU - Postuma, R. B.
AU - Montplaisir, J. Y.
AU - Pelletier, A.
AU - Dauvilliers, Y.
AU - Oertel, W.
AU - Iranzo, A.
AU - Ferini-Strambi, L.
AU - Arnulf, I.
AU - Hogl, B.
AU - Manni, R.
AU - Miyamoto, T.
AU - Mayer, G.
AU - Stiasny-Kolster, K.
AU - Puligheddu, M.
AU - Ju, Y.
AU - Jennum, P.
AU - Sonka, K.
AU - Santamaria, J.
AU - Fantini, M. L.
AU - Zucconi, M.
AU - Leu-Semenescu, S.
AU - Frauscher, B.
AU - Terzaghi, M.
AU - Miyamoto, M.
AU - Unger, M. M.
AU - De Cock, V. Cochen
AU - Wolfson, C.
N1 - Funding Information:
Study funding: Funded by grants from the Fonds de la Recherche en Sante Quebec.
PY - 2012/7/31
Y1 - 2012/7/31
N2 - Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder. Methods: Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors. Results: A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were male. Cases were more likely to smoke (ever smokers = 64.0% vs 55.5%, adjusted odds ratio [OR] = 1.43, p = 0.028). Caffeine and alcohol use were not different between cases and controls. Cases were more likely to report previous head injury (19.3% vs 12.7%, OR=1.59, p=0.037). Cases had fewer years of formal schooling (11.1 ± 4.4 years vs 12.7 ± 4.3, p < 0.001), and were more likely to report having worked Abstract: farmers (19.7% vs 12.5% OR = 1.67, p = 0.022) with borderline increase in welding (17.8% vs 12.1%, OR = 1.53, p = 0.063). Previous occupational pesticide exposure was more prevalent in cases than controls (11.8% vs 6.1%, OR = 2.16, p = 0.008). Conclusions: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.
AB - Objective: Idiopathic REM sleep behavior disorder is a parasomnia characterized by dream enactment and is commonly a prediagnostic sign of parkinsonism and dementia. Since risk factors have not been defined, we initiated a multicenter case-control study to assess environmental and lifestyle risk factors for REM sleep behavior disorder. Methods: Cases were patients with idiopathic REM sleep behavior disorder who were free of dementia and parkinsonism, recruited from 13 International REM Sleep Behavior Disorder Study Group centers. Controls were matched according to age and sex. Potential environmental and lifestyle risk factors were assessed via standardized questionnaire. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors. Results: A total of 694 participants (347 patients, 347 controls) were recruited. Among cases, mean age was 67.7 ± 9.6 years and 81.0% were male. Cases were more likely to smoke (ever smokers = 64.0% vs 55.5%, adjusted odds ratio [OR] = 1.43, p = 0.028). Caffeine and alcohol use were not different between cases and controls. Cases were more likely to report previous head injury (19.3% vs 12.7%, OR=1.59, p=0.037). Cases had fewer years of formal schooling (11.1 ± 4.4 years vs 12.7 ± 4.3, p < 0.001), and were more likely to report having worked Abstract: farmers (19.7% vs 12.5% OR = 1.67, p = 0.022) with borderline increase in welding (17.8% vs 12.1%, OR = 1.53, p = 0.063). Previous occupational pesticide exposure was more prevalent in cases than controls (11.8% vs 6.1%, OR = 2.16, p = 0.008). Conclusions: Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.
UR - http://www.scopus.com/inward/record.url?scp=84866120374&partnerID=8YFLogxK
U2 - 10.1212/WNL.0b013e31825dd383
DO - 10.1212/WNL.0b013e31825dd383
M3 - Article
C2 - 22744670
AN - SCOPUS:84866120374
SN - 0028-3878
VL - 79
SP - 428
EP - 434
JO - Neurology
JF - Neurology
IS - 5
ER -