Environmental control of immunological synapse formation and duration

Michael L. Dustin, Paul M. Allen, Andrey S. Shaw

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


The coordination of T-cell migration and antigen recognition is crucial for an effective immune response. We have proposed that this coordination is achieved by formation of an immunological synapse between the T cell and the antigen-presenting cell (APC). Our view contrasts with the serial encounter model also proposed in this issue of Trends in Immunology, which is based on transient T cell-APC interactions when surrounded by collagen. Here, we propose a model that reconciles immunological synapse formation and serial encounters based on environmental control of immunological synapse formation.

Original languageEnglish
Pages (from-to)192-194
Number of pages3
JournalTrends in Immunology
Issue number4
StatePublished - Jan 1 2001


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