Entropic compression of interacting DNA loops

Sumithra Sankararaman; John F. Marko

doi:10.1103/PhysRevLett.95.078104

Entropic compression of interacting DNA loops

Sumithra Sankararaman, John F. Marko

Section of Medical Oncology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We solve a model for the equilibrium folding of DNA via the formation of randomly placed (nonspecific) loops. We find that the loop rearrangement entropy drives a significant reduction in loop size as more loops form. The reduction of the most probable loop size occurs over a wide range of forces and is enhanced by interloop cooperativity, indicating that it should be observable in single DNA experiments.

Original language	English
Article number	078104
Journal	Physical Review Letters
Volume	95
Issue number	7
DOIs	https://doi.org/10.1103/PhysRevLett.95.078104
State	Published - Aug 12 2005

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10.1103/PhysRevLett.95.078104

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abstract = "We solve a model for the equilibrium folding of DNA via the formation of randomly placed (nonspecific) loops. We find that the loop rearrangement entropy drives a significant reduction in loop size as more loops form. The reduction of the most probable loop size occurs over a wide range of forces and is enhanced by interloop cooperativity, indicating that it should be observable in single DNA experiments.",

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Entropic compression of interacting DNA loops

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