@article{d2fafb4b3b434dd98a116f59804af7d9,
title = "Enterobacteriaceae Act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis",
abstract = "Disruption of homeostasis between the host immune system and the intestinal microbiota leads to inflammatory bowel disease (IBD). Whether IBD is instigated by individual species or disruptions of entire microbial communities remains controversial. We characterized the fecal microbial communities in the recently described T-bet-/- × Rag2-/- ulcerative colitis (TRUC) model driven by T-bet deficiency in the innate immune system. 16S rRNA-based analysis of TRUC and Rag2-/- mice revealed distinctive communities that correlate with host genotype. The presence of Klebsiella pneumoniae and Proteus mirabilis correlates with colitis in TRUC animals, and these TRUC-derived strains can elicit colitis in Rag2-/- and WT adults but require a maternally transmitted endogenous microbial community for maximal intestinal inflammation. Cross-fostering experiments indicated a role for these organisms in maternal transmission of disease. Our findings illustrate how gut microbial communities work in concert with specific culturable colitogenic agents to cause IBD.",
author = "Garrett, {Wendy S.} and Gallini, {Carey A.} and Tanya Yatsunenko and Monia Michaud and Andrea Dubois and Delaney, {Mary L.} and Shivesh Punit and Maria Karlsson and Lynn Bry and Glickman, {Jonathan N.} and Gordon, {Jeffrey I.} and Onderdonk, {Andrew B.} and Glimcher, {Laurie H.}",
note = "Funding Information: We thank J. Braun (UCLA), D. Relman (Stanford U.), A. Swidsinski (Charite Humboldt U.), G. Hansson (U. of Gothenburg), and members of the Gordon and Glimcher labs for helpful discussions. We thank J. Ramirez for care of our SPF mice and S. Wagoner, V.Yesliseyev, and C. Belzer for care of germ-free TRUC. This work was supported by the NIH (CA112663 to L.H.G.), Danone Research (L.H.G.), and the Crohn's and Colitis Foundation of America (J.I.G.), plus career development awards from the Burroughs Wellcome Fund and the NIH (K08AI078942) to W.S.G. The HDDC germ-free core is supported by P30-DK03485. 454 pyrosequencing reads have been deposited in the NCBI Short Read Archive. L.H.G. declares that she is a member of the Board of Directors of the Bristol-Myers Squibb Corporation (BMSC) and holds equity in BMSC. ",
year = "2010",
month = sep,
day = "16",
doi = "10.1016/j.chom.2010.08.004",
language = "English",
volume = "8",
pages = "292--300",
journal = "Cell Host and Microbe",
issn = "1931-3128",
number = "3",
}