Enhancing nerve regeneration across a silicone tube conduit by using interposed short-segment nerve grafts

Paul C. Francel, Thomas J. Francel, Susan E. Mackinnon, Cathy Hertl

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Isolated nerve segments may inherently contain all of the necessary factors required to support regeneration within a silicone tube Conduit placed across a nerve gap. Thirty-six adult Lewis rata each weighing approximately 250 g were randomized into three groups. A sciatic nerve gap (13-15 mm in length) was bridged by an empty silicone tube (Group I), a silicone tube containing a short 2-mm interposed nerve segment (Group II), or a nerve autograft (Group III). At 16 weeks postoperatively, no regeneration was observed through the empty silicone tube. In contrast, regeneration across the silicone tube containing the isolated nerve segment was equivalent to that noted through nerve autografts as assessed by histological, electrophysiological, and functional criteria. Thus, an interposed nerve segment will extend the length of successful nerve regeneration through a silicone tube conduit.

Original languageEnglish
Pages (from-to)887-892
Number of pages6
JournalJournal of neurosurgery
Volume87
Issue number6
DOIs
StatePublished - Dec 1997
Externally publishedYes

Keywords

  • Histological, electrophysiological, and functional results
  • Interposed nerve graft
  • Nerve regeneration
  • Silicone tube

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