Enhancing dopamine tone modulates global and local cortical perfusion as a function of COMT val158met genotype

Keyphrases

• Genotype 100%
• Dopamine 100%
• Catechol-O-methyltransferase 100%
• COMT Val158Met 100%
• Cortical Perfusion 100%
• Perfusion Changes 40%
• Homozygote 40%
• Drug Response 40%
• Tolcapone 40%
• Placebo 20%
• Striatal Dopamine 20%
• Healthy Individuals 20%
• Dopamine System 20%
• Perfusion 20%
• Executive Function 20%
• System Function 20%
• Genetic Polymorphism 20%
• Arterial Spin Labeling 20%
• Common Polymorphism 20%
• Bromocriptine 20%
• Cognitive Effects 20%
• Human Adult 20%
• Dopamine Activity 20%
• Dopamine D2 20%
• Inverted U-shape 20%
• Meaningful Information 20%
• Drug-induced 20%
• Within-subject Design 20%
• Inverted-U 20%
• Right Inferior Frontal Gyrus (rIFG) 20%
• U-model 20%
• Rs4680 20%
• Track Prediction 20%
• Catechol-O-methyltransferase Inhibitors 20%
• Rs1800497 20%
• U-shaped Functions 20%

Neuroscience

• Methyltransferase 100%
• Individual Differences 33%
• Tolcapone 33%
• Dopaminergic 16%
• Placebo 16%
• Agonist 16%
• Inferior Frontal Gyrus 16%
• Arterial Spin Labeling 16%
• Genetic Polymorphism 16%
• Bromocriptine 16%
• Cognitive Effect 16%
• Executive Function 16%