TY - JOUR
T1 - Enhancing DNA vaccine potency by modifying the properties of antigen-presenting cells
AU - Tsen, Shaw Wei D.
AU - Paik, Augustine H.
AU - Hung, Chien Fu
AU - Wu, T. C.
PY - 2007/4
Y1 - 2007/4
N2 - DNA vaccines represent a potentially promising approach for antigen-specific immunotherapy. Advances in our knowledge of the adaptive immune system have indicated that professional antigen-presenting cells, especially dendritic cells (DCs), play a key role in the generation of antigen-specific immune responses. Thus, the modification of the properties of DCs represents an important strategy for enhancing the potency of DNA vaccines. This review discusses strategies to increase the number of antigen-expressing DCs, enhance antigen expression, processing and presentation in DCs, promote the activation and function of DCs, and improve DC and T-cell interaction, in order to optimize DNA vaccine-elicited immune responses. Continuing progress in our understanding of DC and T-cell biology serves as a foundation for further improvement of DNA vaccine potency, which may lead to future clinical applications of DNA vaccines for the control of infectious diseases and malignancies.
AB - DNA vaccines represent a potentially promising approach for antigen-specific immunotherapy. Advances in our knowledge of the adaptive immune system have indicated that professional antigen-presenting cells, especially dendritic cells (DCs), play a key role in the generation of antigen-specific immune responses. Thus, the modification of the properties of DCs represents an important strategy for enhancing the potency of DNA vaccines. This review discusses strategies to increase the number of antigen-expressing DCs, enhance antigen expression, processing and presentation in DCs, promote the activation and function of DCs, and improve DC and T-cell interaction, in order to optimize DNA vaccine-elicited immune responses. Continuing progress in our understanding of DC and T-cell biology serves as a foundation for further improvement of DNA vaccine potency, which may lead to future clinical applications of DNA vaccines for the control of infectious diseases and malignancies.
KW - Antigen-presenting cells
KW - DNA vaccines
KW - Dendritic cells
UR - http://www.scopus.com/inward/record.url?scp=34247188123&partnerID=8YFLogxK
U2 - 10.1586/14760584.6.2.227
DO - 10.1586/14760584.6.2.227
M3 - Review article
C2 - 17408372
AN - SCOPUS:34247188123
VL - 6
SP - 227
EP - 239
JO - Expert Review of Vaccines
JF - Expert Review of Vaccines
SN - 1476-0584
IS - 2
ER -