The effect of the synthetic adjuvant MDP (N-acetyl-muramyl-L-alanyl-D-isoglutamine) on the generation of antigen-specific suppression was investigated. Suppression of the anti-bovine serum albumin response, which was achieved by intravenous administration of a peptic fragment of the antigen, was greatly enhanced by simultaneous administration of MDP. Induction of suppression by a combination of bovine serum albumin fragments and MDP was found to be antigen specific and appeared to occur via the generation of antigen-specific suppressor T cells.

Original languageEnglish
Pages (from-to)800-806
Number of pages7
JournalInfection and immunity
Issue number2
StatePublished - 1983


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