Enhanced optical scattering by microbubbles

Quing Zhu; Britton Chance; W. Timothy Jenkins; Yu Tao Zhang

doi:10.1117/12.280242

Enhanced optical scattering by microbubbles

Quing Zhu
, Britton Chance
, W. Timothy Jenkins
, Yu Tao Zhang

Department of Biomedical Engineering

Research output: Contribution to journal › Conference article › peer-review

5 Scopus citations

Abstract

Optical properties of microbubbles (EchoGen, Sonus Pharmaceuticals, WA) have been evaluated using a 200 MHz phase modulation system. Studies have shown that the mean optical pathlength has been increased at 754 nm by an average of 1.5 mm (std. 0.46 mm) when EchoGen was administered to 11 fischer rats at the dose of 100 μl or 150 μl. As a comparison, the mean pathlength has been decreased at the same wavelength by an average of 4.2 mm (std. 3.66 mm) when Indocyanine Green (ICG) was administered at the dose of 100 μl. The mean pathlength change at 816 nm is very small and the possible reasons are discussed. Potential applications of using microbubbles to provide a co-registration of ultrasound and light images of growing tumors are discussed.

Original language	English
Pages (from-to)	157-162
Number of pages	6
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	2979
DOIs	https://doi.org/10.1117/12.280242
State	Published - 1997
Event	Proceedings of Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model and Human Studies II - San Jose, CA, United States Duration: Feb 9 1997 → Feb 12 1997

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@article{f599f337fd5c46048afb0cc3377ab9c6,

title = "Enhanced optical scattering by microbubbles",

abstract = "Optical properties of microbubbles (EchoGen, Sonus Pharmaceuticals, WA) have been evaluated using a 200 MHz phase modulation system. Studies have shown that the mean optical pathlength has been increased at 754 nm by an average of 1.5 mm (std. 0.46 mm) when EchoGen was administered to 11 fischer rats at the dose of 100 μl or 150 μl. As a comparison, the mean pathlength has been decreased at the same wavelength by an average of 4.2 mm (std. 3.66 mm) when Indocyanine Green (ICG) was administered at the dose of 100 μl. The mean pathlength change at 816 nm is very small and the possible reasons are discussed. Potential applications of using microbubbles to provide a co-registration of ultrasound and light images of growing tumors are discussed.",

author = "Quing Zhu and Britton Chance and Jenkins, \{W. Timothy\} and Zhang, \{Yu Tao\}",

year = "1997",

doi = "10.1117/12.280242",

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pages = "157--162",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

note = "Proceedings of Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model and Human Studies II ; Conference date: 09-02-1997 Through 12-02-1997",

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TY - JOUR

T1 - Enhanced optical scattering by microbubbles

AU - Zhu, Quing

AU - Chance, Britton

AU - Jenkins, W. Timothy

AU - Zhang, Yu Tao

PY - 1997

Y1 - 1997

N2 - Optical properties of microbubbles (EchoGen, Sonus Pharmaceuticals, WA) have been evaluated using a 200 MHz phase modulation system. Studies have shown that the mean optical pathlength has been increased at 754 nm by an average of 1.5 mm (std. 0.46 mm) when EchoGen was administered to 11 fischer rats at the dose of 100 μl or 150 μl. As a comparison, the mean pathlength has been decreased at the same wavelength by an average of 4.2 mm (std. 3.66 mm) when Indocyanine Green (ICG) was administered at the dose of 100 μl. The mean pathlength change at 816 nm is very small and the possible reasons are discussed. Potential applications of using microbubbles to provide a co-registration of ultrasound and light images of growing tumors are discussed.

AB - Optical properties of microbubbles (EchoGen, Sonus Pharmaceuticals, WA) have been evaluated using a 200 MHz phase modulation system. Studies have shown that the mean optical pathlength has been increased at 754 nm by an average of 1.5 mm (std. 0.46 mm) when EchoGen was administered to 11 fischer rats at the dose of 100 μl or 150 μl. As a comparison, the mean pathlength has been decreased at the same wavelength by an average of 4.2 mm (std. 3.66 mm) when Indocyanine Green (ICG) was administered at the dose of 100 μl. The mean pathlength change at 816 nm is very small and the possible reasons are discussed. Potential applications of using microbubbles to provide a co-registration of ultrasound and light images of growing tumors are discussed.

UR - https://www.scopus.com/pages/publications/0031289102

U2 - 10.1117/12.280242

DO - 10.1117/12.280242

M3 - Conference article

AN - SCOPUS:0031289102

SN - 0277-786X

VL - 2979

SP - 157

EP - 162

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Proceedings of Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model and Human Studies II

Y2 - 9 February 1997 through 12 February 1997

ER -

Enhanced optical scattering by microbubbles

Abstract

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