Summary: Dunbar, Bowman, and colleagues present here a novel genetic mouse model with inducible and reversible expression of the JAK2V617F mutation in the endogenous locus. Results from this study clearly demonstrate an absolute requirement for myeloproliferative neoplasm–initiating cells for this mutation in their survival and imply that more efficacious inhibitors could be curative for these patients even in the setting of additional cooperating mutations.

Original languageEnglish
Pages (from-to)701-703
Number of pages3
JournalCancer discovery
Issue number5
StatePublished - May 1 2024


Dive into the research topics of 'Enhanced Molecular Response in Myeloproliferative Neoplasms with Complete JAK2V617F Inhibition'. Together they form a unique fingerprint.

Cite this