TY - JOUR
T1 - Engulfment of apoptotic cells
T2 - Signals for a good meal
AU - Ravichandran, Kodi S.
AU - Lorenz, Ulrike
N1 - Funding Information:
The authors wish to thank colleagues in the engulfment field and members of our laboratories for many insightful discussions. This work was supported by grants GM064709 and GM069998 (to K.S.R.) and AI48672 (to U.L.).
PY - 2007/11/21
Y1 - 2007/11/21
N2 - The clearance of apoptotic cells by phagocytes is an integral component of normal life, and defects in this process can have significant implications for self tolerance and autoimmunity. Recent studies have provided new insights into the engulfment process, including how phagocytes seek apoptotic cells, how they recognize and ingest these targets and how they maintain cellular homeostasis after the 'meal'. Several new factors that regulate engulfment have been identified, whereas the roles of some of the older players require revision. This Review focuses on these recent developments and attempts to highlight some of the important questions in this field.
AB - The clearance of apoptotic cells by phagocytes is an integral component of normal life, and defects in this process can have significant implications for self tolerance and autoimmunity. Recent studies have provided new insights into the engulfment process, including how phagocytes seek apoptotic cells, how they recognize and ingest these targets and how they maintain cellular homeostasis after the 'meal'. Several new factors that regulate engulfment have been identified, whereas the roles of some of the older players require revision. This Review focuses on these recent developments and attempts to highlight some of the important questions in this field.
UR - http://www.scopus.com/inward/record.url?scp=36448961645&partnerID=8YFLogxK
U2 - 10.1038/nri2214
DO - 10.1038/nri2214
M3 - Review article
C2 - 18037898
AN - SCOPUS:36448961645
SN - 1474-1733
VL - 7
SP - 964
EP - 974
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 12
ER -