TY - JOUR
T1 - Engineering targeted viral vectors for gene therapy
AU - Waehler, Reinhard
AU - Russell, Stephen J.
AU - Curiel, David T.
N1 - Funding Information:
This work was supported with a grant by the German Research Foundation (DFG) to R.W., with grants from the US National Institutes of Health (NIH) to S.J.R. and grants from the NIH and the US Department of Defense (DOD) to D.T.C. The authors wish to thank J. Roth, J. T. Douglas, S. J. Hedley, S. Ponnazhagan, Q. L. Matthews, M. Everts and J. N. Glasgow for their critical reading of the manuscript.
PY - 2007/8/3
Y1 - 2007/8/3
N2 - To achieve therapeutic success, transfer vehicles for gene therapy must be capable of transducing target cells while avoiding impact on non-target cells. Despite the high transduction efficiency of viral vectors, their tropism frequently does not match the therapeutic need. In the past, this lack of appropriate targeting allowed only partial exploitation of the great potential of gene therapy. Substantial progress in modifying viral vectors using diverse techniques now allows targeting to many cell types in vitro. Although important challenges remain for in vivo applications, the first clinical trials with targeted vectors have already begun to take place.
AB - To achieve therapeutic success, transfer vehicles for gene therapy must be capable of transducing target cells while avoiding impact on non-target cells. Despite the high transduction efficiency of viral vectors, their tropism frequently does not match the therapeutic need. In the past, this lack of appropriate targeting allowed only partial exploitation of the great potential of gene therapy. Substantial progress in modifying viral vectors using diverse techniques now allows targeting to many cell types in vitro. Although important challenges remain for in vivo applications, the first clinical trials with targeted vectors have already begun to take place.
UR - http://www.scopus.com/inward/record.url?scp=34447535345&partnerID=8YFLogxK
U2 - 10.1038/nrg2141
DO - 10.1038/nrg2141
M3 - Review article
C2 - 17607305
AN - SCOPUS:34447535345
SN - 1471-0056
VL - 8
SP - 573
EP - 587
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 8
ER -