Abstract
Main conclusion: This review summarizes recent advances in cyanobacterial terpenoid production. The challenges and opportunities of improving terpenoid production by cyanobacteria are discussed. Terpenoids are a diverse group of natural products with a variety of commercial applications. With recent advances in synthetic biology and metabolic engineering, microbial terpenoid synthesis is being viewed as a feasible approach for industrial production. Among different microbial hosts, cyanobacteria have the potential of sustainable production of terpenoids using light and CO 2 . Terpene synthases and the precursor pathways have been expressed in cyanobacteria for enhanced production of various terpene hydrocarbons, including isoprene, limonene, β-phellandrene, and farnesene. However, the productivities need to be further improved for commercial production. Many barriers remain to be overcome in order to efficiently convert CO 2 to terpenoids. In this review, we will summarize recent efforts on photosynthetic production of terpenoids and discuss the challenges and opportunities of engineering cyanobacteria for terpenoid bioproduction.
| Original language | English |
|---|---|
| Pages (from-to) | 145-154 |
| Number of pages | 10 |
| Journal | Planta |
| Volume | 249 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 31 2019 |
Keywords
- Cyanobacteria
- MEP pathway
- MVA pathway
- Metabolic engineering
- Terpenoid