TY - JOUR
T1 - Engaging and disengaging recurrent inhibition coincides with sensing and unsensing of a sensory stimulus
AU - Saha, Debajit
AU - Sun, Wensheng
AU - Li, Chao
AU - Nizampatnam, Srinath
AU - Padovano, William
AU - Chen, Zhengdao
AU - Chen, Alex
AU - Altan, Ege
AU - Lo, Ray
AU - Barbour, Dennis L.
AU - Raman, Baranidharan
N1 - Publisher Copyright:
© The Author(s) 2017.
PY - 2017/5/23
Y1 - 2017/5/23
N2 - Even simple sensory stimuli evoke neural responses that are dynamic and complex. Are the temporally patterned neural activities important for controlling the behavioral output? Here, we investigated this issue. Our results reveal that in the insect antennal lobe, due to circuit interactions, distinct neural ensembles are activated during and immediately following the termination of every odorant. Such non-overlapping response patterns are not observed even when the stimulus intensity or identities were changed. In addition, we find that ON and OFF ensemble neural activities differ in their ability to recruit recurrent inhibition, entrain field-potential oscillations and more importantly in their relevance to behaviour (initiate versus reset conditioned responses). Notably, we find that a strikingly similar strategy is also used for encoding sound onsets and offsets in the marmoset auditory cortex. In sum, our results suggest a general approach where recurrent inhibition is associated with stimulus 'recognition' and 'derecognition'.
AB - Even simple sensory stimuli evoke neural responses that are dynamic and complex. Are the temporally patterned neural activities important for controlling the behavioral output? Here, we investigated this issue. Our results reveal that in the insect antennal lobe, due to circuit interactions, distinct neural ensembles are activated during and immediately following the termination of every odorant. Such non-overlapping response patterns are not observed even when the stimulus intensity or identities were changed. In addition, we find that ON and OFF ensemble neural activities differ in their ability to recruit recurrent inhibition, entrain field-potential oscillations and more importantly in their relevance to behaviour (initiate versus reset conditioned responses). Notably, we find that a strikingly similar strategy is also used for encoding sound onsets and offsets in the marmoset auditory cortex. In sum, our results suggest a general approach where recurrent inhibition is associated with stimulus 'recognition' and 'derecognition'.
UR - http://www.scopus.com/inward/record.url?scp=85019833219&partnerID=8YFLogxK
U2 - 10.1038/ncomms15413
DO - 10.1038/ncomms15413
M3 - Article
C2 - 28534502
AN - SCOPUS:85019833219
SN - 2041-1723
VL - 8
JO - Nature communications
JF - Nature communications
M1 - 15413
ER -