Energy biogenesis: One key for coordinating two genomes

Marco Sardiello, Gaetano Tripoli, Antonio Romito, Crescenzio Minervini, Luigi Viggiano, Corrado Caggese, Graziano Pesole

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


In metazoan organisms, energy production is the only example of a process that is under dual genetic control: nuclear and mitochondrial. We used a genomic approach to examine how energy genes of both the nuclear and mitochondrial genomes are coordinated, and discovered a novel genetic regulatory circuit in Drosophila melanogaster that is surprisingly simple and parsimonious. This circuit is based on a single DNA regulatory element and can explain both intra- and inter-genomic coordinated expression of genes involved in energy production, including the full complement of mitochondrial and nuclear oxidative phosphorylation genes, and the genes involved in the Krebs cycle.

Original languageEnglish
Pages (from-to)12-16
Number of pages5
JournalTrends in Genetics
Issue number1
StatePublished - Jan 2005


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