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Energetics of thrombin-thrombomodulin interaction
Alessandro Vindigni
, Christopher E. White
, Elizabeth A. Komives
, Enrico Di Cera
Section of Medical Oncology
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Siteman Cancer Center
DBBS - Molecular Cell Biology
DBBS - Molecular Genetics and Genomics
DBBS - Cancer Biology
Research output
:
Contribution to journal
›
Article
›
peer-review
64
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Scopus citations
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Biochemistry, Genetics and Molecular Biology
Binding Site
23%
C-Terminus
7%
Chondroitin Sulfate
30%
Conformational Change
15%
EGF-like Domain
23%
Energy Transfer
100%
Enzymatic Hydrolysis
15%
Enzyme
53%
Fibrinogen
38%
Heparin
23%
Hirudin
7%
Protein C
30%
Ternary Complex
7%
Thrombin
100%
Thrombomodulin
100%
Keyphrases
Binding Protein
7%
C-terminal Fragments
7%
Catalytic Pocket
7%
Chondroitin Sulfate
30%
Chromogenic Substrate
15%
Conformational Change
7%
Conformational Transition
7%
EGF-like
23%
Enzyme-like
7%
Fibrinogen
38%
Heat Capacity Change
15%
Heparin Binding Site
23%
Highly Charged
7%
Hirudin
7%
Na +
7%
Physiological Function
7%
Polyelectrolyte
7%
Recognition Events
7%
Recognition Site
38%
Relative Specificity
7%
Rigid Body
7%
Salt Dependence
15%
SlowFast
7%
Temperature Dependence
7%
Ternary Complex
7%
Thrombin
100%
Thrombomodulin
100%
Chemistry
Binding Site
37%
Chondroitin Sulfate
50%
Cofactor
62%
Conformational Transition
12%
Energetics
100%
Enzymatic Hydrolysis
25%
Heat Capacity
25%
Heparin
37%
Hydrolysis
25%
Protein C
50%
Thrombin
100%