Endpoint surrogacy in oncology Phase 3 randomised controlled trials

Jianrong Zhang; Meagan R. Pilar; Xiaofei Wang; Jingxia Liu; Herbert Pang; Ross C. Brownson; Graham A. Colditz; Wenhua Liang; Jianxing He

doi:10.1038/s41416-020-0896-5

Endpoint surrogacy in oncology Phase 3 randomised controlled trials

Jianrong Zhang, Meagan R. Pilar, Xiaofei Wang, Jingxia Liu, Herbert Pang, Ross C. Brownson, Graham A. Colditz, Wenhua Liang, Jianxing He

Research output: Contribution to journal › Editorial

Abstract

Endpoint surrogacy is an important concept in oncology trials. Using a surrogate endpoint like progression-free survival as the primary endpoint—instead of overall survival—would lead to a potential faster drug approval and therefore more cancer patients with an earlier opportunity to receive the newly approved drugs.

Original language	English
Pages (from-to)	333-334
Number of pages	2
Journal	British Journal of Cancer
Volume	123
Issue number	3
DOIs	https://doi.org/10.1038/s41416-020-0896-5
State	Published - Aug 4 2020

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10.1038/s41416-020-0896-5

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title = "Endpoint surrogacy in oncology Phase 3 randomised controlled trials",

abstract = "Endpoint surrogacy is an important concept in oncology trials. Using a surrogate endpoint like progression-free survival as the primary endpoint—instead of overall survival—would lead to a potential faster drug approval and therefore more cancer patients with an earlier opportunity to receive the newly approved drugs.",

author = "Jianrong Zhang and Pilar, {Meagan R.} and Xiaofei Wang and Jingxia Liu and Herbert Pang and Brownson, {Ross C.} and Colditz, {Graham A.} and Wenhua Liang and Jianxing He",

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AU - Zhang, Jianrong

AU - Pilar, Meagan R.

AU - Wang, Xiaofei

AU - Liu, Jingxia

AU - Pang, Herbert

AU - Brownson, Ross C.

AU - Colditz, Graham A.

AU - Liang, Wenhua

AU - He, Jianxing

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AB - Endpoint surrogacy is an important concept in oncology trials. Using a surrogate endpoint like progression-free survival as the primary endpoint—instead of overall survival—would lead to a potential faster drug approval and therefore more cancer patients with an earlier opportunity to receive the newly approved drugs.

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