TY - JOUR
T1 - Endovascular papillary angioendothelioma of childhood. A vascular lesion possibly characterized by "High" endothelial cell differentiation
AU - Manivel, J. Carlos
AU - Wick, Mark R.
AU - Swanson, Paul E.
AU - Patterson, Kathleen
AU - Dehner, Louis P.
N1 - Funding Information:
Received from the *Department of Laboratory Medicine and Pathology, Division of Surgical Patlmlogy, University of Minnesota Medical School, and the tDepartment of Pathology, George Washington University School of Medicine, Washington, DC. Revision accepted for publication May 14, 1986. Supported by a Career Development Award in Oncology from the American Cancer Society (M.R.W.). Address correspondence and reprint requests to Dr. Manivel: Box 76, Mayo Memorial Building, University of Minnesota Hospital, 420 Delaware Street SE, Minneapolis, MN 55455. 0046-8177/86 $0.00 + .25
PY - 1986/12
Y1 - 1986/12
N2 - Two cases of endovascular papillary angioendothelioma (EPA) of the skin were studied immunohistochemically to assess the expression of endothelial, leukocytic, and epithelial determinants by these lesions. The tumor cells in both cases were labeled by antibodies to Factor VIII-related antigen, vimentin, and blood group isoantigens; they also bound Ulex europaeus I agglutinin. On the other hand, immunoreactivity for epithelial membrane antigen, Leu-M1, HLA-DR (Ia-like antigen), and leukocyte common antigen (LCA) was not observed. Stromal and intravascular lymphocytes were labeled intensely with antibodies to LCA and HLA-DR and were intimately associated with papillary configurations of proliferating intravascular tumor cells. These results confirm the endothelial nature of EPA and suggest that the cells of this lesion may differentiate toward "high" endothelial cells, which have been shown to interact functionally with circulating lymphocytes.
AB - Two cases of endovascular papillary angioendothelioma (EPA) of the skin were studied immunohistochemically to assess the expression of endothelial, leukocytic, and epithelial determinants by these lesions. The tumor cells in both cases were labeled by antibodies to Factor VIII-related antigen, vimentin, and blood group isoantigens; they also bound Ulex europaeus I agglutinin. On the other hand, immunoreactivity for epithelial membrane antigen, Leu-M1, HLA-DR (Ia-like antigen), and leukocyte common antigen (LCA) was not observed. Stromal and intravascular lymphocytes were labeled intensely with antibodies to LCA and HLA-DR and were intimately associated with papillary configurations of proliferating intravascular tumor cells. These results confirm the endothelial nature of EPA and suggest that the cells of this lesion may differentiate toward "high" endothelial cells, which have been shown to interact functionally with circulating lymphocytes.
UR - http://www.scopus.com/inward/record.url?scp=0022907516&partnerID=8YFLogxK
U2 - 10.1016/S0046-8177(86)80567-6
DO - 10.1016/S0046-8177(86)80567-6
M3 - Article
C2 - 3539759
AN - SCOPUS:0022907516
SN - 0046-8177
VL - 17
SP - 1240
EP - 1244
JO - Human Pathology
JF - Human Pathology
IS - 12
ER -