Endothelial nitric oxide synthase gene single-nucleotide polymorphism predicts cerebral vasospasm after aneurysmal subarachnoid hemorrhage

Robert M. Starke, Grace H. Kim, Ricardo J. Komotar, Zachary L. Hickman, Eric M. Black, Maritza B. Rosales, Christopher P. Kellner, David K. Hahn, Marc L. Otten, John Edwards, Tao Wang, James J. Russo, Stephan A. Mayer, Edward S. Connolly

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Vasospasm is a major cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (aSAH). Studies have shown a link between single-nucleotide polymorphisms (SNPs) in the endothelial nitric oxide synthase (eNOS) gene and the incidence of coronary spasm and aneurysms. Alterations in the eNOS T-786 SNP may lead to an increased risk of post-aSAH cerebral vasospasm. In this prospective clinical study, 77 aSAH patients provided genetic material and were followed for the occurrence of vasospasm. In multivariate logistic regression analysis, genotype was the only factor predictive of vasospasm. The odds ratio (OR) for symptomatic vasospasm in patients with one T allele was 3.3 (95% confidence interval (CI): 1.1 to 10.0, P=0.034) and 10.9 for TT. Patients with angiographic spasm were 3.6 times more likely to have a T allele (95% CI: 1.3 to 9.6, P=0.013; for TT: OR 12.6). Patients with severe vasospasm requiring endovascular therapy were more likely to have a T allele (OR 3.5, 95% CI: 1.3 to 9.5, P=0.016; for TT: OR 12.0). Patients with the T allele of the eNOS gene are more likely to have severe vasospasm. Presence of this genotype may allow the identification of individuals at high risk for post-aSAH vasospasm and lead to early treatment and improved outcome.

Original languageEnglish
Pages (from-to)1204-1211
Number of pages8
JournalJournal of Cerebral Blood Flow and Metabolism
Volume28
Issue number6
DOIs
StatePublished - Jun 30 2008
Externally publishedYes

Keywords

  • Endothelial nitric oxide synthase
  • Intracranial aneurysm
  • Nitric oxide
  • Polymorphism
  • Subarachnoid hemorrhage
  • Vasospasm

Fingerprint Dive into the research topics of 'Endothelial nitric oxide synthase gene single-nucleotide polymorphism predicts cerebral vasospasm after aneurysmal subarachnoid hemorrhage'. Together they form a unique fingerprint.

  • Cite this

    Starke, R. M., Kim, G. H., Komotar, R. J., Hickman, Z. L., Black, E. M., Rosales, M. B., Kellner, C. P., Hahn, D. K., Otten, M. L., Edwards, J., Wang, T., Russo, J. J., Mayer, S. A., & Connolly, E. S. (2008). Endothelial nitric oxide synthase gene single-nucleotide polymorphism predicts cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Journal of Cerebral Blood Flow and Metabolism, 28(6), 1204-1211. https://doi.org/10.1038/jcbfm.2008.11