Endosomal membrane traffic: Convergence point targeted by Mycobacterium tuberculosis and HIV

Vojo Deretic, Isabelle Vergne, Jennifer Chua, Sharon Master, Sudha B. Singh, Joseph A. Fazio, George Kyei

Research output: Contribution to journalShort surveypeer-review

38 Scopus citations

Abstract

Inhibition of phagolysosome biogenesis in infected macrophages is a classical pathogenesis determinant of Mycobacterium tuberculosis. In this review we primarily cover the cellular mechanisms of M. tuberculosis phagosome maturation arrest. A detailed picture is beginning to emerge, involving regulators of membrane trafficking in mammalian cells and phagosomal interactions with endosomal organelles and the trans-Golgi network. We also present a hypothesis that overlaps may exist between the mycobacterial interference with the host cell membrane trafficking processes and the targeting of the late endosomal sorting machinery by HIV during viral budding in macrophages. We propose that interference with the endosomal sorting machinery contributes to the synergism between the two significant human diseases - AIDS and tuberculosis.

Original languageEnglish
Pages (from-to)999-1009
Number of pages11
JournalCellular microbiology
Volume6
Issue number11
DOIs
StatePublished - Nov 2004

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