Increasing evidence suggests that stress signaling pathways emanating from the endoplasmic reticulum (ER) are important to the pathogenesis of both type 1 and type 2 diabetes. Recent observations indicate that ER stress signaling participates in maintaining the ER homeostasis of pancreatic β-cells. Either a high level of ER stress or defective ER stress signaling in β-cells may cause an imbalance in ER homeostasis and lead to β-cell apoptosis and autoimmune response. In addition, it has been suggested that ER stress attributes to insulin resistance in patients with type 2 diabetes. It is necessary to study the relationship between ER stress and diabetes in order to develop new therapeutic approaches to diabetes based on drugs that block the ER stress-mediated cell-death pathway and insulin resistance.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalCurrent Molecular Medicine
Issue number1
StatePublished - Feb 2006


  • EIF2AK3 gene
  • JNK-inhibitory peptide
  • PKR-like ER kinase (PERK)
  • Pro-apoptotic factors
  • Wolcott-Rallison Syndrome


Dive into the research topics of 'Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes'. Together they form a unique fingerprint.

Cite this