TY - JOUR
T1 - Endogenous cholinergic modulation of growth-hormone secretion in normal and acromegalic humans
AU - Leveston, Steven A.
AU - Cryer, Philip E.
N1 - Funding Information:
From the Metabolism Division, Washington University School of Medicine, St. Louis, Missouri. Receivefdo r publication May 30. I979. Supported in part by USPHS grants AM20579 and RR00036. and by a grant from the Diabetic Children’s Welfare Association/American Diabetes Association, Greater St. Louis AJiliate. Address reprint requests to Philip E. Cryer. Metabolism Division, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO. 63110. o 1980 by Grune & Stratton. Inc. 0026-0495j80j2908-ooo2%oI .00/O
PY - 1980
Y1 - 1980
N2 - Endogenous cholinergic stimulation, produced by the intravenous injection of edrophonium (10 mg), an acetylcholinesterase inhibitor, into 8 normal human subjects, resulted in an increase in the mean (±SE) serum growth hormone (GH) concentration from 0.6 ± 0.1 ng/ml to 5.6 ± 1.4 ng/ml (p < 0.01) at 40 min with no changes in serum prolactin. In 2 subjects sampled for 140 min, maximum serum GH levels of 19.4 and 10.2 ng/ml (from baseline values of 0.4 and 0.6 ng/ml) occurred at 65 min after edrophonium injection. Thus, enhancement of endogenous cholinergic activity stimulates GH secretion, providing further evidence for a role of cholinergic mechanisms in the physiologic regulation of GH secretion in man. The theoretical possibility that excessive endogenous cholinergic activity might be involved in the pathophysiologic regulation of GH secretion in acromegaly was not, however, supported, since methscopolamine (0.5 mg s.c.), a cholinergic antagonist, did not reduce mean serum GH levels in 3 acromegalic patients.
AB - Endogenous cholinergic stimulation, produced by the intravenous injection of edrophonium (10 mg), an acetylcholinesterase inhibitor, into 8 normal human subjects, resulted in an increase in the mean (±SE) serum growth hormone (GH) concentration from 0.6 ± 0.1 ng/ml to 5.6 ± 1.4 ng/ml (p < 0.01) at 40 min with no changes in serum prolactin. In 2 subjects sampled for 140 min, maximum serum GH levels of 19.4 and 10.2 ng/ml (from baseline values of 0.4 and 0.6 ng/ml) occurred at 65 min after edrophonium injection. Thus, enhancement of endogenous cholinergic activity stimulates GH secretion, providing further evidence for a role of cholinergic mechanisms in the physiologic regulation of GH secretion in man. The theoretical possibility that excessive endogenous cholinergic activity might be involved in the pathophysiologic regulation of GH secretion in acromegaly was not, however, supported, since methscopolamine (0.5 mg s.c.), a cholinergic antagonist, did not reduce mean serum GH levels in 3 acromegalic patients.
UR - http://www.scopus.com/inward/record.url?scp=0018954881&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(80)90191-2
DO - 10.1016/0026-0495(80)90191-2
M3 - Article
C2 - 7402075
AN - SCOPUS:0018954881
VL - 29
SP - 703
EP - 706
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 8
ER -