Endocytosis and signaling cascades: A close encounter

Valeria Cavalli, Michela Corti, Jean Gruenberg

Research output: Contribution to journalShort survey

80 Scopus citations

Abstract

Internalization of receptors and other cell surface components is well known to occur via clathrin-mediated endocytosis, although other less well characterized pathways are also involved. Internalized receptors are then delivered to early endosomes, where they are sorted to be recycled back to the plasma membrane for reutilization or transported to late endosomes/lysosomes for degradation. Endocytosis has long been considered as a constitutive, housekeeping function of animal cells that occurs independently of the cellular environment in contrast to regulated secretion. Here, we will discuss recent studies that are uncovering the existence of cross-talk between signaling molecules and components of the transport machinery, indicating that endocytosis can be modulated by signaling pathways.

Original languageEnglish
Pages (from-to)190-196
Number of pages7
JournalFEBS Letters
Volume498
Issue number2-3
DOIs
StatePublished - Jun 8 2001

Keywords

  • Actin
  • Clathrin
  • FYVE protein
  • Growth factor
  • Phosphoinositide
  • Rab protein
  • Signal transduction
  • Traffic

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