TY - JOUR
T1 - Endobronchial ultrasound-guided intranodal forceps biopsy (EBUS-IFB)—technical review
AU - Cheng, George
AU - Mahajan, Amit
AU - Oh, Scott
AU - Benzaquen, Sadia
AU - Chen, Alexander
N1 - Publisher Copyright:
© Journal of Thoracic Disease. All rights reserved.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Endobronchial ultrasound (EBUS) and transbronchial needle aspiration (TBNA) have changed the landscape of pulmonology. Mediastinal structures beyond the confines of airway walls are visualized in real-time with EBUS, leading to improved accuracy of tissue sampling and diagnostic yield. With the development of various needle sizes ranging from 25-G to 19-G, the sampling of lymph nodes is becoming easier and more commonplace. Yet, certain conditions such as sarcoidosis and lymphoma may still be difficult to diagnose via EBUS-TBNA. Furthermore, in the age of targeted therapy, there are more demands on EBUS-TBNA samples for molecular marker testing and next-generation sequencing. Here, we present a complementary methodology, EBUS-guided intranodal forceps biopsy (EBUS-IFB), for tissue acquisition that may help address these deficiencies. Specifically, we aim to propose indications, contraindications, outline approaches in performing IFB, and provide an overview of the data for this complementary technique.
AB - Endobronchial ultrasound (EBUS) and transbronchial needle aspiration (TBNA) have changed the landscape of pulmonology. Mediastinal structures beyond the confines of airway walls are visualized in real-time with EBUS, leading to improved accuracy of tissue sampling and diagnostic yield. With the development of various needle sizes ranging from 25-G to 19-G, the sampling of lymph nodes is becoming easier and more commonplace. Yet, certain conditions such as sarcoidosis and lymphoma may still be difficult to diagnose via EBUS-TBNA. Furthermore, in the age of targeted therapy, there are more demands on EBUS-TBNA samples for molecular marker testing and next-generation sequencing. Here, we present a complementary methodology, EBUS-guided intranodal forceps biopsy (EBUS-IFB), for tissue acquisition that may help address these deficiencies. Specifically, we aim to propose indications, contraindications, outline approaches in performing IFB, and provide an overview of the data for this complementary technique.
KW - Endobronchial ultrasound (EBUS)
KW - Intranodal forceps biopsy (IFB)
KW - Lymphadenopathy
KW - Miniforceps biopsy
KW - Transbronchial needle aspiration (TBNA)
UR - http://www.scopus.com/inward/record.url?scp=85073770066&partnerID=8YFLogxK
U2 - 10.21037/jtd.2019.08.106
DO - 10.21037/jtd.2019.08.106
M3 - Review article
C2 - 31656681
AN - SCOPUS:85073770066
SN - 2072-1439
VL - 11
SP - 4049
EP - 4058
JO - Journal of Thoracic Disease
JF - Journal of Thoracic Disease
IS - 9
ER -