TY - JOUR
T1 - End-to-side neurorrhaphy resulting in limited sensory axonal regeneration in a rat model
AU - Tarasidis, Gregory
AU - Strasberg, Suzanne R.
AU - Watanabe, Osamu
AU - Haughey, Bruce H.
AU - Mackinnon, Susan E.
AU - Hunter, Daniel A.
PY - 1997
Y1 - 1997
N2 - This study evaluated reinnervation of an end-to-side neurorrhaphy and the resultant functional recovery in a rat model. The cut distal posterior tibial nerve was repaired to the side of an intact peroneal nerve. In one group, the epineurium of the peroneal nerve was left intact; in another group, the epineurium was stripped; in the third experimental group, a perineurial slit was created. Evaluations included walking track analysis, nerve conduction studies, muscle mass measurements, retrograde nerve tracing, and histologic evaluation. Walking tracks indicated poor functional recovery. No significant difference in nerve conduction between the experimental and control groups was seen. Gastrocnemius muscle mass measurements revealed no functional recovery in the end-to-side groups. Retrograde nerve tracing revealed minimal staining of motor neurons. However, sensory neuronal staining of the dorsal root ganglia occurred in all groups. Histology revealed minimal myelinated axonal regeneration. These results suggest that predominantly sensory neural regeneration occurs in an end-to-side neurorrhaphy at an end point of 16 weeks.
AB - This study evaluated reinnervation of an end-to-side neurorrhaphy and the resultant functional recovery in a rat model. The cut distal posterior tibial nerve was repaired to the side of an intact peroneal nerve. In one group, the epineurium of the peroneal nerve was left intact; in another group, the epineurium was stripped; in the third experimental group, a perineurial slit was created. Evaluations included walking track analysis, nerve conduction studies, muscle mass measurements, retrograde nerve tracing, and histologic evaluation. Walking tracks indicated poor functional recovery. No significant difference in nerve conduction between the experimental and control groups was seen. Gastrocnemius muscle mass measurements revealed no functional recovery in the end-to-side groups. Retrograde nerve tracing revealed minimal staining of motor neurons. However, sensory neuronal staining of the dorsal root ganglia occurred in all groups. Histology revealed minimal myelinated axonal regeneration. These results suggest that predominantly sensory neural regeneration occurs in an end-to-side neurorrhaphy at an end point of 16 weeks.
KW - End-to-side neurorrhaphy
KW - Horseradish peroxidase
KW - Lewis rat
KW - Nerve conduction
KW - Peripheral nerve regeneration
KW - Walking track analysis
UR - http://www.scopus.com/inward/record.url?scp=0030998436&partnerID=8YFLogxK
U2 - 10.1177/000348949710600612
DO - 10.1177/000348949710600612
M3 - Article
C2 - 9199612
AN - SCOPUS:0030998436
SN - 0003-4894
VL - 106
SP - 506
EP - 512
JO - Annals of Otology, Rhinology and Laryngology
JF - Annals of Otology, Rhinology and Laryngology
IS - 6
ER -